ID   IUTA_KLEPN              Reviewed;         733 AA.
AC   Q6U607;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Ferric aerobactin receptor;
DE   AltName: Full=Iron-regulated outer membrane proteins;
DE            Short=IROMPs;
DE   Flags: Precursor;
GN   Name=iutA; ORFNames=LV107;
OS   Klebsiella pneumoniae.
OG   Plasmid pLVPK.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CG43;
RX   PubMed=15276215; DOI=10.1016/j.gene.2004.05.008;
RA   Chen Y.-T., Chang H.-Y., Lai Y.-C., Pan C.-C., Tsai S.-F., Peng H.-L.;
RT   "Sequencing and analysis of the large virulence plasmid pLVPK of Klebsiella
RT   pneumoniae CG43.";
RL   Gene 337:189-198(2004).
RN   [2]
RP   FUNCTION AS AN AEROBACTIN RECEPTOR, INDUCTION, AND SUBCELLULAR LOCATION.
RA   Williams P., Chart H., Griffiths E., Stevenson P.;
RT   "Expression of high affinity iron uptake systems by clinical isolates of
RT   Klebsiella.";
RL   FEMS Microbiol. Lett. 44:407-412(1987).
CC   -!- FUNCTION: Receptor for aerobactin. {ECO:0000269|Ref.2}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000269|Ref.2}.
CC   -!- INDUCTION: Under iron starvation. {ECO:0000269|Ref.2}.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       {ECO:0000305}.
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DR   EMBL; AY378100; AAR07714.1; -; Genomic_DNA.
DR   RefSeq; NP_943364.1; NC_005249.1.
DR   RefSeq; WP_004213924.1; NZ_WYAM01000033.1.
DR   AlphaFoldDB; Q6U607; -.
DR   SMR; Q6U607; -.
DR   PHI-base; PHI:6563; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015344; F:siderophore uptake transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0019271; P:aerobactin transport; ISS:UniProtKB.
DR   GO; GO:0055072; P:iron ion homeostasis; ISS:UniProtKB.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   InterPro; IPR039426; BtuB-like.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR010916; TonB_box_CS.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   InterPro; IPR010917; TonB_rcpt_CS.
DR   InterPro; IPR010105; TonB_sidphr_rcpt.
DR   PANTHER; PTHR30069; PTHR30069; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   TIGRFAMs; TIGR01783; TonB-siderophor; 1.
DR   PROSITE; PS00430; TONB_DEPENDENT_REC_1; 1.
DR   PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Ion transport; Iron; Iron transport; Membrane;
KW   Plasmid; Receptor; Signal; TonB box; Transport.
FT   SIGNAL          1..25
FT   CHAIN           26..733
FT                   /note="Ferric aerobactin receptor"
FT                   /id="PRO_0000415650"
FT   MOTIF           31..38
FT                   /note="TonB box"
FT                   /evidence="ECO:0000250"
FT   MOTIF           716..733
FT                   /note="TonB C-terminal box"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   733 AA;  80853 MW;  3CC6ED07B19467D9 CRC64;
     MMISKKYTLW ALNPLLLTMM APAVAQQTDD ETFVVSANRS NRTVAEMAQT TWVIENAELE
     QQIQGGKELK DALAQLIPGL DVSSRSRTNY GMNVRGRPLV VLVDGVRLNS SRTDSRQLDS
     IDPFNIDRIE VISGATSLYG GGSTGGLINI VTKKGQPETI MEFEAGTKSG FSSSKDHDER
     IAGAVSGGNE HISGRLSVAY QKFGGWFDGN GDATLLDNTQ TGLQYSDRLD IMGTGTLNID
     ESRQLQLITQ YYKSQGDDDY GLNLGKGFSA IRGTSTPFVS NGLNSDRIPG TERHLISLQY
     SDSAFLGQEL VGQVYYRDES LRFYPFPTVN ANKQVTAFSS SQQDTDQYGM KLTLNSKPMD
     GWQITWGLDA DHERFTSNQM FFDLAQASAS GGLNNKKIYT TGRYPSYDIT NLAAFLQSGY
     DINNLFTLNG GVRYQYTENK IDDFIGYAQQ RQIAAGKATS ADAIPGGSVD YDNFLFNAGL
     LMHITERQQA WLNFSQGVEL PDPGKYYGRG IYGAAVNGHL PLTKSVNVSD SKLEGVKVDS
     YELGWRFTGN NLRTQIAAYY SISDKSVVAN KDLTISVVDD KRRIYGVEGA VDYLIPDTDW
     STGVNFNVLK TESKVNGTWQ KYDVKTASPS KATAYIGWAP DPWSLRVQST TSFDVSDAQG
     YKVDGYTTVD LLGSYQLPVG TLSFSIENLF DRDYTTVWGQ RAPLYYSPGY GPASLYDYKG
     RGRTFGLNYS VLF