ID   IVBI3_HOPST             Reviewed;          83 AA.
AC   B5L5R6;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 2.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Stephenin-3;
DE   Flags: Precursor;
OS   Hoplocephalus stephensii (Stephens' banded snake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Notechinae; Hoplocephalus.
OX   NCBI_TaxID=196418;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Venom gland;
RX   PubMed=18979207; DOI=10.1007/s00018-008-8573-5;
RA   St Pierre L., Earl S.T., Filippovich I., Sorokina N., Masci P.P.,
RA   De Jersey J., Lavin M.F.;
RT   "Common evolution of waprin and Kunitz-like toxin families in Australian
RT   venomous snakes.";
RL   Cell. Mol. Life Sci. 65:4039-4054(2008).
CC   -!- FUNCTION: Serine protease inhibitor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ACC77803.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; EU401854; ACC77803.1; ALT_FRAME; Genomic_DNA.
DR   AlphaFoldDB; B5L5R6; -.
DR   SMR; B5L5R6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd00109; KU; 1.
DR   Gene3D; 4.10.410.10; -; 1.
DR   InterPro; IPR002223; Kunitz_BPTI.
DR   InterPro; IPR036880; Kunitz_BPTI_sf.
DR   InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR   Pfam; PF00014; Kunitz_BPTI; 1.
DR   PRINTS; PR00759; BASICPTASE.
DR   SMART; SM00131; KU; 1.
DR   SUPFAM; SSF57362; SSF57362; 1.
DR   PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR   PROSITE; PS50279; BPTI_KUNITZ_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Protease inhibitor; Secreted; Serine protease inhibitor;
KW   Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..83
FT                   /note="Stephenin-3"
FT                   /id="PRO_5000395654"
FT   DOMAIN          31..80
FT                   /note="BPTI/Kunitz inhibitor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        31..80
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        40..63
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        55..76
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
SQ   SEQUENCE   83 AA;  9095 MW;  8A809992CCF2E00F CRC64;
     MSSGGLLLLL GLLTLWEVLT PVSSKDRPEF CELPADPGPC NALSQAYYNA VQHKCLKFRY
     GGCKANPNTF KTIEECKRTC AGK