IVD_CAEEL
ID IVD_CAEEL Reviewed; 408 AA.
AC P34275;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 19-DEC-2001, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Probable acyl-CoA dehydrogenase 6;
DE AltName: Full=Probable isovaleryl-CoA dehydrogenase;
DE Short=IVD;
DE EC=1.3.8.4;
GN Name=acdh-6; ORFNames=C02D5.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer
CC flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-
CC transfer flavoprotein]; Xref=Rhea:RHEA:12276, Rhea:RHEA-COMP:10685,
CC Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57344,
CC ChEBI:CHEBI:57345, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307; EC=1.3.8.4;
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC -!- PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-
CC 3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3.
CC -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the acyl-CoA dehydrogenase family.
CC {ECO:0000305}.
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DR EMBL; FO080279; CCD62557.1; -; Genomic_DNA.
DR PIR; S44743; S44743.
DR RefSeq; NP_498885.1; NM_066484.1.
DR AlphaFoldDB; P34275; -.
DR SMR; P34275; -.
DR STRING; 6239.C02D5.1; -.
DR EPD; P34275; -.
DR PaxDb; P34275; -.
DR PeptideAtlas; P34275; -.
DR PRIDE; P34275; -.
DR EnsemblMetazoa; C02D5.1.1; C02D5.1.1; WBGene00015335.
DR GeneID; 182112; -.
DR KEGG; cel:CELE_C02D5.1; -.
DR UCSC; C02D5.1; c. elegans.
DR CTD; 182112; -.
DR WormBase; C02D5.1; CE24778; WBGene00015335; acdh-6.
DR eggNOG; KOG0139; Eukaryota.
DR GeneTree; ENSGT00940000164410; -.
DR HOGENOM; CLU_018204_0_3_1; -.
DR InParanoid; P34275; -.
DR OMA; FITNGTW; -.
DR OrthoDB; 589058at2759; -.
DR PhylomeDB; P34275; -.
DR UniPathway; UPA00363; UER00860.
DR PRO; PR:P34275; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00015335; Expressed in embryo and 3 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0003995; F:acyl-CoA dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0008470; F:isovaleryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0033539; P:fatty acid beta-oxidation using acyl-CoA dehydrogenase; IBA:GO_Central.
DR GO; GO:0006552; P:leucine catabolic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.540.10; -; 1.
DR Gene3D; 2.40.110.10; -; 1.
DR InterPro; IPR006089; Acyl-CoA_DH_CS.
DR InterPro; IPR006091; Acyl-CoA_Oxase/DH_mid-dom.
DR InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR InterPro; IPR036250; AcylCo_DH-like_C.
DR InterPro; IPR009075; AcylCo_DH/oxidase_C.
DR InterPro; IPR013786; AcylCoA_DH/ox_N.
DR InterPro; IPR037069; AcylCoA_DH/ox_N_sf.
DR InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom.
DR Pfam; PF00441; Acyl-CoA_dh_1; 1.
DR Pfam; PF02770; Acyl-CoA_dh_M; 1.
DR Pfam; PF02771; Acyl-CoA_dh_N; 1.
DR SUPFAM; SSF47203; SSF47203; 1.
DR SUPFAM; SSF56645; SSF56645; 1.
DR PROSITE; PS00072; ACYL_COA_DH_1; 1.
DR PROSITE; PS00073; ACYL_COA_DH_2; 1.
PE 3: Inferred from homology;
KW FAD; Flavoprotein; Oxidoreductase; Reference proteome.
FT CHAIN 1..408
FT /note="Probable acyl-CoA dehydrogenase 6"
FT /id="PRO_0000201191"
FT ACT_SITE 265
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
SQ SEQUENCE 408 AA; 45326 MW; A6351C6DCDCA962D CRC64;
MAFLARKTSS LLPATTSSTV KHMIYDEPHF AMQNSLAKLI KEKINPNVAQ WEKSGRYPAH
FVFKMLGQLG VFAVNKPVDY GGTGRDFAMS IAIAEQIGAV DCGSIPMSVM VQSDMSTPAL
AQFGSDSLRN RFLRPSINGD LVSSIAVSEP HAGSDVSAIR THARRYGSDL IINGSKMWIT
NGDQADWACV LVNTSNAKNL HKNKSLVCIP LDSIGVHRST PLDKLGMRSS DTVQLFFEDV
RVPSSYIIGE EGRGFAYQMN QFNDERLVTV AVGLLPLQKC INETIEYARE RLIFGKTLLD
QQYVQFRLAE LEAELEATRS LLYRTVLARC QGEDVSMLTA MAKLKIGRLA RKVTDQCLQI
WGGAGYLNDN GISRAFRDFR IFSIGAGCDE VMMQIIHKTQ SKRQQKRI
