IVN1_SCHPO
ID IVN1_SCHPO Reviewed; 371 AA.
AC Q96WW4; O13599;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Invasion protein 1;
GN Name=ivn1; ORFNames=pi004, SPACTOKYO_453.33c, SPBC11B10.07c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1] {ECO:0000312|EMBL:BAA21381.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=10620777;
RX DOI=10.1002/(sici)1097-0061(20000115)16:1<71::aid-yea505>3.0.co;2-5;
RA Machida M., Yamazaki S., Kunihiro S., Tanaka T., Kushida N., Jinno K.,
RA Haikawa Y., Yamazaki J., Yamamoto S., Sekine M., Oguchi A., Nagai Y.,
RA Sakai M., Aoki K., Ogura K., Kudoh Y., Kikuchi H., Zhang M.Q., Yanagida M.;
RT "A 38 kb segment containing the cdc2 gene from the left arm of fission
RT yeast chromosome II: sequence analysis and characterization of the genomic
RT DNA and cDNAs encoded on the segment.";
RL Yeast 16:71-80(2000).
RN [2] {ECO:0000312|EMBL:CAC37511.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3] {ECO:0000305}
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [4]
RP FUNCTION.
RX PubMed=19542312; DOI=10.1128/ec.00078-09;
RA Dodgson J., Avula H., Hoe K.L., Kim D.U., Park H.O., Hayles J.,
RA Armstrong J.;
RT "Functional genomics of adhesion, invasion, and mycelial formation in
RT Schizosaccharomyces pombe.";
RL Eukaryot. Cell 8:1298-1306(2009).
CC -!- FUNCTION: Required for invasive growth. {ECO:0000269|PubMed:19542312}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000269|PubMed:16823372}. Membrane {ECO:0000255}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the CDC50/LEM3 family. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA21381.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB004534; BAA21381.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CU329671; CAC37511.1; -; Genomic_DNA.
DR RefSeq; NP_595627.1; NM_001021521.2.
DR AlphaFoldDB; Q96WW4; -.
DR SMR; Q96WW4; -.
DR BioGRID; 276281; 35.
DR STRING; 4896.SPBC11B10.07c.1; -.
DR MaxQB; Q96WW4; -.
DR PaxDb; Q96WW4; -.
DR EnsemblFungi; SPBC11B10.07c.1; SPBC11B10.07c.1:pep; SPBC11B10.07c.
DR GeneID; 2539729; -.
DR KEGG; spo:SPBC11B10.07c; -.
DR PomBase; SPBC11B10.07c; ivn1.
DR VEuPathDB; FungiDB:SPBC11B10.07c; -.
DR eggNOG; KOG2952; Eukaryota.
DR HOGENOM; CLU_025025_0_1_1; -.
DR InParanoid; Q96WW4; -.
DR OMA; AWQPMLS; -.
DR PhylomeDB; Q96WW4; -.
DR PRO; PR:Q96WW4; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; ISO:PomBase.
DR GO; GO:0005770; C:late endosome; ISO:PomBase.
DR GO; GO:1990531; C:phospholipid-translocating ATPase complex; ISO:PomBase.
DR GO; GO:0005886; C:plasma membrane; ISO:PomBase.
DR GO; GO:0045332; P:phospholipid translocation; ISO:PomBase.
DR InterPro; IPR005045; CDC50/LEM3_fam.
DR PANTHER; PTHR10926; PTHR10926; 1.
DR Pfam; PF03381; CDC50; 1.
DR PIRSF; PIRSF015840; DUF284_TM_euk; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..371
FT /note="Invasion protein 1"
FT /id="PRO_0000316867"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 99
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 212
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 216
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 233
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 284
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 297
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 371 AA; 42421 MW; E1C2D56A1A72CDE5 CRC64;
MSQTEIVKKP KHKRFKRPDK SRFVQQTLPA WQFIFTPWTV LPLLFLLGIV FAPLGAGMFV
ASRRVKELRI DYTDCMNIGD EFKQVPSTNI EFQYKNVKNV TAMWKSSGDV CTLRFQIPEE
MTSPVFAFYR LKNFYQNHRR YTVSADMFQL LGEARTVAQL KSYGFCKPLE ANEEGKPYYP
CGIIANSLFN DSYSSLLRYE SFDSSNSLGL YNMTTNGTAW PEDRERYKKT KYNASQIVPP
PNWAKMFPNG YTDDNIPDVS TWDAFQIWMR AAALPTFSKL ALRNVTTALQ PGIYEMNITY
NFPVTEYKGT KTIMFSTTSV IGGKNYFLGI LYFVIGGLCA ASGVILSIAC LIKPRRVGDP
RYLSWNRGKS S
