IVY_PSEAE
ID IVY_PSEAE Reviewed; 153 AA.
AC Q9HXB1;
DT 11-JUL-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Inhibitor of vertebrate lysozyme;
DE Flags: Precursor;
GN Name=ivy; OrderedLocusNames=PA3902;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
RN [2]
RP CHARACTERIZATION.
RA Abergel C.;
RL Unpublished observations (DEC-2001).
CC -!- FUNCTION: Strong inhibitor of lysozyme C.
CC -!- SUBUNIT: Monomer.
CC -!- SUBCELLULAR LOCATION: Periplasm.
CC -!- SIMILARITY: Belongs to the ivy family. {ECO:0000305}.
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DR EMBL; AE004091; AAG07289.1; -; Genomic_DNA.
DR PIR; A83159; A83159.
DR RefSeq; NP_252591.1; NC_002516.2.
DR RefSeq; WP_003093002.1; NZ_QZGE01000001.1.
DR PDB; 1UUZ; X-ray; 1.80 A; A/B=25-153.
DR PDB; 4PS6; X-ray; 1.25 A; A=25-153.
DR PDBsum; 1UUZ; -.
DR PDBsum; 4PS6; -.
DR AlphaFoldDB; Q9HXB1; -.
DR SMR; Q9HXB1; -.
DR DIP; DIP-60906N; -.
DR IntAct; Q9HXB1; 1.
DR STRING; 287.DR97_3964; -.
DR PaxDb; Q9HXB1; -.
DR PRIDE; Q9HXB1; -.
DR DNASU; 878927; -.
DR EnsemblBacteria; AAG07289; AAG07289; PA3902.
DR GeneID; 878927; -.
DR KEGG; pae:PA3902; -.
DR PATRIC; fig|208964.12.peg.4087; -.
DR PseudoCAP; PA3902; -.
DR HOGENOM; CLU_109262_1_0_6; -.
DR InParanoid; Q9HXB1; -.
DR OMA; KPHDCAN; -.
DR PhylomeDB; Q9HXB1; -.
DR BioCyc; PAER208964:G1FZ6-3975-MON; -.
DR EvolutionaryTrace; Q9HXB1; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.
DR Gene3D; 3.40.1420.10; -; 1.
DR InterPro; IPR036501; Inhibitor_vert_lysozyme_sf.
DR InterPro; IPR014453; Inhibitor_vertebrate_lysozyme.
DR PIRSF; PIRSF009103; Ivy; 1.
DR SUPFAM; SSF89872; SSF89872; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Disulfide bond; Periplasm; Reference proteome; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..153
FT /note="Inhibitor of vertebrate lysozyme"
FT /id="PRO_0000016547"
FT SITE 86
FT /note="Important for lysozyme inhibition"
FT /evidence="ECO:0000250"
FT DISULFID 83..88
FT STRAND 25..27
FT /evidence="ECO:0007829|PDB:4PS6"
FT HELIX 30..33
FT /evidence="ECO:0007829|PDB:4PS6"
FT HELIX 37..46
FT /evidence="ECO:0007829|PDB:4PS6"
FT TURN 47..49
FT /evidence="ECO:0007829|PDB:4PS6"
FT HELIX 55..59
FT /evidence="ECO:0007829|PDB:4PS6"
FT STRAND 67..72
FT /evidence="ECO:0007829|PDB:4PS6"
FT STRAND 75..83
FT /evidence="ECO:0007829|PDB:4PS6"
FT TURN 88..90
FT /evidence="ECO:0007829|PDB:4PS6"
FT STRAND 91..98
FT /evidence="ECO:0007829|PDB:4PS6"
FT STRAND 104..110
FT /evidence="ECO:0007829|PDB:4PS6"
FT HELIX 116..119
FT /evidence="ECO:0007829|PDB:4PS6"
FT HELIX 122..124
FT /evidence="ECO:0007829|PDB:4PS6"
FT STRAND 127..132
FT /evidence="ECO:0007829|PDB:4PS6"
FT HELIX 136..147
FT /evidence="ECO:0007829|PDB:4PS6"
SQ SEQUENCE 153 AA; 16905 MW; AE64BE633EE77020 CRC64;
MNGVSRLLSL ALLGAALHWA PAQAEEQPRL FELLGQPGYK ATWHAMFKGE SDVPKWVSDA
SGPSSPSTSL SLEGQPYVLA NSCKPHDCGN NRLLVAFRGD KSAAYGLQVS LPDEPAEVMQ
TPSKYATYRW YGEPSRQVRE LLMKQLESDP NWK
