ID   IWR1_SCHPO              Reviewed;         277 AA.
AC   O13951;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=RNA polymerase II nuclear localization protein iwr1;
GN   Name=iwr1; ORFNames=SPAC23H4.08;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Directs RNA polymerase II nuclear import. {ECO:0000250}.
CC   -!- SUBUNIT: Associates with RNA polymerase II. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=shuttles between the nucleus and cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IWR1/SLC7A6OS family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB11662.1; -; Genomic_DNA.
DR   PIR; T38320; T38320.
DR   RefSeq; NP_593398.1; NM_001018830.2.
DR   AlphaFoldDB; O13951; -.
DR   BioGRID; 278281; 250.
DR   STRING; 4896.SPAC23H4.08.1; -.
DR   iPTMnet; O13951; -.
DR   MaxQB; O13951; -.
DR   PaxDb; O13951; -.
DR   PRIDE; O13951; -.
DR   EnsemblFungi; SPAC23H4.08.1; SPAC23H4.08.1:pep; SPAC23H4.08.
DR   GeneID; 2541789; -.
DR   KEGG; spo:SPAC23H4.08; -.
DR   PomBase; SPAC23H4.08; iwr1.
DR   VEuPathDB; FungiDB:SPAC23H4.08; -.
DR   eggNOG; ENOG502TAB0; Eukaryota.
DR   HOGENOM; CLU_1066196_0_0_1; -.
DR   InParanoid; O13951; -.
DR   OMA; YVYDIYE; -.
DR   PhylomeDB; O13951; -.
DR   PRO; PR:O13951; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; ISO:PomBase.
DR   GO; GO:0005634; C:nucleus; ISO:PomBase.
DR   GO; GO:0006606; P:protein import into nucleus; ISO:PomBase.
DR   InterPro; IPR040150; Iwr1.
DR   InterPro; IPR013883; TF_Iwr1_dom.
DR   PANTHER; PTHR28063; PTHR28063; 2.
DR   Pfam; PF08574; Iwr1; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..277
FT                   /note="RNA polymerase II nuclear localization protein iwr1"
FT                   /id="PRO_0000339140"
FT   REGION          222..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        254..277
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   277 AA;  31711 MW;  E1AC5DB33F449BDF CRC64;
     MPLPVLRVKR KASEDPVNAL YLELGNNPNS VSSTKRRKFA GRYYFKLSQT LKQDDRYIQI
     NDESSEPTHE DVRNIHSHTK ISSLKKNNYG IPVVQTSEDV VKAPTHMDLG SRENTKGILS
     FSSPRYTIQN LPSTQSNRVF DAIRVEQGHT TYHPHPQLDS MIQEYLSNGD LPLQQSTEDY
     VYDIYEASSK EPNKPTFAYG VIDALSIPDA FRSSLEQELV SETVDSDKDD PLHDEIDEDS
     NAESFYQNSY PDEDEWQDSS ENDEFAYSDD AEQDFYD