ID   IWS1A_XENLA             Reviewed;         836 AA.
AC   Q6DE96; Q8AVS0;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Protein IWS1 homolog A;
DE   AltName: Full=IWS1-like protein A;
GN   Name=iws1-a; Synonyms=iws1l-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor which plays a key role in defining the
CC       composition of the RNA polymerase II (RNAPII) elongation complex and in
CC       modulating the production of mature mRNA transcripts. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649}.
CC   -!- SIMILARITY: Belongs to the IWS1 family. {ECO:0000305}.
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DR   EMBL; BC041492; AAH41492.1; -; mRNA.
DR   EMBL; BC077238; AAH77238.1; -; mRNA.
DR   RefSeq; NP_001082530.1; NM_001089061.1.
DR   AlphaFoldDB; Q6DE96; -.
DR   SMR; Q6DE96; -.
DR   DNASU; 398541; -.
DR   GeneID; 398541; -.
DR   KEGG; xla:398541; -.
DR   CTD; 398541; -.
DR   Xenbase; XB-GENE-6256046; iws1.S.
DR   OrthoDB; 380765at2759; -.
DR   Proteomes; UP000186698; Chromosome 5S.
DR   Bgee; 398541; Expressed in gastrula and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.930.10; -; 1.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR017923; TFIIS_N.
DR   Pfam; PF08711; Med26; 1.
DR   PROSITE; PS51319; TFIIS_N; 1.
PE   2: Evidence at transcript level;
KW   mRNA processing; mRNA splicing; mRNA transport; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Transport.
FT   CHAIN           1..836
FT                   /note="Protein IWS1 homolog A"
FT                   /id="PRO_0000083349"
FT   DOMAIN          631..709
FT                   /note="TFIIS N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00649"
FT   REGION          1..542
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          714..746
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..256
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        263..279
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        287..477
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        478..505
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        509..525
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        526..542
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        715..731
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        138
FT                   /note="S -> C (in Ref. 1; AAH41492)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        269
FT                   /note="D -> G (in Ref. 1; AAH41492)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        281..282
FT                   /note="Missing (in Ref. 1; AAH41492)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   836 AA;  92703 MW;  356E5C30FFE8CC2B CRC64;
     MEADNYSPEH SDDGGATPVQ DERDSASDDE GNEQRSEPGS PEHQSEDEHS DVEDHKHSSD
     SGSDNEKGTE HDSEDEHRPR NSSDLENHDA SDSENEESHN RIASDSEDDG RRQKNSDSDR
     SPVKGAASDS DEEPVRHSAS DSEDDVPRKQ QANDSEDERH IKKTASDSED EAPAKHRVSD
     TEDKAPPKQV ASDSEDEASP KQVASDSKDE APPKHAASDS EDEAPPKLAG SDSEDEAPAK
     RKVSSSEDET PSKHAVSASK VKKSVGSEDK TRGKRAIIDS DDDDDDDVPV KRAASDSEEE
     THPKGKASDS EDEAPSKQPS DSEEETPAKV AANDSEDEFP RMKRKIVSSD DSDDEDDRKP
     LQKKKKSPRR SSESDSSDKV DGKKLQASES DEEGEKASKK KKSNIVSDSE DEDAADKSGN
     KKSRILSDGE DSDSDAASEK PKQKKKKSAS SDSEEEDERK SKTETKSADK LFGSESDSEN
     EEENLIADIF GESGDEEEEE FTGFNQEDLE GEKTVTSVNR QQAAAADSDS DDDMKSGKMG
     DYKSDFDLML ERKKSMSGKQ RRNRDGGTFI SDADDVVNAM IMKMTEAAEE DRNLNSSKKP
     ALKKLTLLPT VVMHLKKQDL KETFIDSGVM SAIKEWLTPL PDRSLPALKI REELLKILQE
     LPSVSQETLK HSGIGRAIMY LYKHPKESRP NKDIAGKLIN EWSRPIFGLT SNYKGMTREE
     REQRDIEQMP QRRRMSSSGG QTPRRDLDKV LTGEEKALRP GEPGFCARAR VPLPSNKDYV
     VRPKWNVEME TSQYQGSAKK GVSRIDKQMR KFVDIKKKNR FGHAVKISIE GNKMPL