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IWS1_ASHGO
ID   IWS1_ASHGO              Reviewed;         370 AA.
AC   Q75EH2;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Transcription factor IWS1;
GN   Name=IWS1; OrderedLocusNames=AAR107W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Transcription factor involved in RNA polymerase II
CC       transcription regulation. May function in both SPT15/TBP post-
CC       recruitment and recruitment steps of transcription (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649}.
CC   -!- SIMILARITY: Belongs to the IWS1 family. {ECO:0000305}.
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DR   EMBL; AE016814; AAS50472.1; -; Genomic_DNA.
DR   RefSeq; NP_982648.1; NM_208001.1.
DR   AlphaFoldDB; Q75EH2; -.
DR   SMR; Q75EH2; -.
DR   STRING; 33169.AAS50472; -.
DR   EnsemblFungi; AAS50472; AAS50472; AGOS_AAR107W.
DR   GeneID; 4618445; -.
DR   KEGG; ago:AGOS_AAR107W; -.
DR   eggNOG; KOG1793; Eukaryota.
DR   HOGENOM; CLU_045275_0_0_1; -.
DR   InParanoid; Q75EH2; -.
DR   OMA; VAEWTRP; -.
DR   Proteomes; UP000000591; Chromosome I.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000993; F:RNA polymerase II complex binding; IEA:EnsemblFungi.
DR   GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:EnsemblFungi.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR   GO; GO:0034243; P:regulation of transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   Gene3D; 1.20.930.10; -; 1.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR017923; TFIIS_N.
DR   Pfam; PF08711; Med26; 1.
DR   PROSITE; PS51319; TFIIS_N; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..370
FT                   /note="Transcription factor IWS1"
FT                   /id="PRO_0000083353"
FT   DOMAIN          182..259
FT                   /note="TFIIS N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00649"
FT   REGION          1..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..61
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   370 AA;  41269 MW;  2B1B634159DCC546 CRC64;
     MSGSSSVHSG TAASEEWGMP SVGEIGAAGE AVETNEVERA QHQERQRKHI ATSDNDEEES
     GNKWSVSTLP ITSYGGDGDA AGGSGRRQAL EAKMERLLKK PKARHSRQDE EDLEQYLDEK
     ILRLKDEMNM AAQKDIETLN RRLETGDNRL IAMEKVTLLP KVISVLNKAN LADTILDNNL
     LQSVRIWLEP LPDGSLPSFE IQKSLFAAIE NLPIKTEHLK ESGLGKVVIF YTKSKRVEHK
     LARLADRLVA EWTRPIIGAS DNYRDKRVLK MDFDVEKHRK KAALDSAKSK KRRKAAVDEE
     KHKSLYELAA AKRNRAAAPA QTTTDYKYAP VSNISNVQTG IRTAGVGSTL NNNDLYKRLN
     SRLAKSKRSK
 
 
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