IWS1_ASPFU
ID IWS1_ASPFU Reviewed; 460 AA.
AC Q4WSM6; Q8TGF8;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Transcription factor iws1;
GN Name=iws1; ORFNames=AfA14E5.15c, AFUA_1G12260;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=14998527; DOI=10.1016/j.fgb.2003.12.003;
RA Pain A., Woodward J.R., Quail M.A., Anderson M.J., Clark R., Collins M.,
RA Fosker N., Fraser A., Harris D.E., Larke N., Murphy L.D., Humphray S.,
RA O'Neil S., Pertea M., Price C., Rabbinowitsch E., Rajandream M.A.,
RA Salzberg S.L., Saunders D., Seeger K., Sharp S., Warren T., Denning D.W.,
RA Barrell B.G., Hall N.;
RT "Insight into the genome of Aspergillus fumigatus: analysis of a 922 kb
RT region encompassing the nitrate assimilation gene cluster.";
RL Fungal Genet. Biol. 41:443-453(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Transcription factor involved in RNA polymerase II
CC transcription regulation. May function in both SPT15/TBP post-
CC recruitment and recruitment steps of transcription (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649}.
CC -!- SIMILARITY: Belongs to the IWS1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAD27305.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAE47953.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EAL90556.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL683874; CAD27305.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BX649605; CAE47953.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AAHF01000004; EAL90556.2; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_752594.2; XM_747501.2.
DR AlphaFoldDB; Q4WSM6; -.
DR SMR; Q4WSM6; -.
DR STRING; 746128.CADAFUBP00001152; -.
DR PRIDE; Q4WSM6; -.
DR GeneID; 3510557; -.
DR KEGG; afm:AFUA_1G12260; -.
DR eggNOG; KOG1793; Eukaryota.
DR HOGENOM; CLU_045275_1_0_1; -.
DR InParanoid; Q4WSM6; -.
DR OrthoDB; 1461546at2759; -.
DR Proteomes; UP000002530; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR Gene3D; 1.20.930.10; -; 1.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR Pfam; PF08711; Med26; 1.
DR SUPFAM; SSF47676; SSF47676; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..460
FT /note="Transcription factor iws1"
FT /id="PRO_0000083354"
FT DOMAIN 277..354
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00649"
FT REGION 1..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..100
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 460 AA; 52663 MW; 82F890ABA4D4BA0B CRC64;
MSDSPEMQPA SPSDVVSTHE FQRDLPEEPE NAPTPGGDED HNEEAPEEGA ASATPAAESV
AETHEDDPAD KEDAGVDSDE ESILSEVDEA QFEDFDPENV DIEDRPQLAI DEDNLKLIGR
HKRKRTEEDG QQVKRKREGR REKKNRRRDM EEGLDEGEDK SRRRDRKKRD ATPEDEELLD
PATRRRRALD RAMDEALKKP TKRRFRKADG IDLEQMADAE IEDMRKRMTH AAQMDANNRR
EGRPAMHKLK MLPEVVSLLN RNQYVNSLVD PEINLLEAVK FFLEPLDDGS LPAYNIQRDL
MTALSKLPIN KETLIASGIG KVIVFYTKSK RPEPGIKRMA ERLLAEWTRP ILQRSDDYSK
RVYQEAEYDP SPHAHKYYRK LTTRTTSAQA SVAEARSREL LPPRLANRAR PEITHTSYTI
VPRPTVVQES KFARPLGASG EDRFRRMRAR QIAASKGSRR
