ID   IWS1_CAEEL              Reviewed;         511 AA.
AC   Q19375;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=IWS1-like protein;
GN   ORFNames=F13B12.1 {ECO:0000312|WormBase:F13B12.1};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649}.
CC   -!- SIMILARITY: Belongs to the IWS1 family. {ECO:0000305}.
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DR   EMBL; Z70683; CAA94590.1; -; Genomic_DNA.
DR   PIR; T20820; T20820.
DR   RefSeq; NP_501924.1; NM_069523.4.
DR   AlphaFoldDB; Q19375; -.
DR   SMR; Q19375; -.
DR   BioGRID; 43036; 8.
DR   IntAct; Q19375; 1.
DR   MINT; Q19375; -.
DR   STRING; 6239.F13B12.1; -.
DR   iPTMnet; Q19375; -.
DR   EPD; Q19375; -.
DR   PaxDb; Q19375; -.
DR   PeptideAtlas; Q19375; -.
DR   PRIDE; Q19375; -.
DR   EnsemblMetazoa; F13B12.1.1; F13B12.1.1; WBGene00008729.
DR   GeneID; 177934; -.
DR   KEGG; cel:CELE_F13B12.1; -.
DR   UCSC; F13B12.1.1; c. elegans.
DR   CTD; 177934; -.
DR   WormBase; F13B12.1; CE05599; WBGene00008729; -.
DR   eggNOG; KOG1793; Eukaryota.
DR   GeneTree; ENSGT00940000169144; -.
DR   HOGENOM; CLU_040584_1_0_1; -.
DR   InParanoid; Q19375; -.
DR   OMA; EDMRRYD; -.
DR   OrthoDB; 1461546at2759; -.
DR   PhylomeDB; Q19375; -.
DR   Reactome; R-CEL-112382; Formation of RNA Pol II elongation complex.
DR   Reactome; R-CEL-674695; RNA Polymerase II Pre-transcription Events.
DR   Reactome; R-CEL-75955; RNA Polymerase II Transcription Elongation.
DR   PRO; PR:Q19375; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00008729; Expressed in embryo and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; HDA:WormBase.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR   Gene3D; 1.20.930.10; -; 1.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR017923; TFIIS_N.
DR   Pfam; PF08711; Med26; 1.
DR   PROSITE; PS51319; TFIIS_N; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..511
FT                   /note="IWS1-like protein"
FT                   /id="PRO_0000083352"
FT   DOMAIN          294..374
FT                   /note="TFIIS N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00649"
FT   REGION          1..200
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          382..454
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..39
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        63..88
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..169
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        176..200
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        382..443
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   511 AA;  57253 MW;  2893C048682D1125 CRC64;
     MSDHEEESHG ASPTSPASSG ASSPLAPISP RSEGNAPESP SGDVQDIYKD ESFEAPASPA
     RDSSAPASPS AASPAGSRSP SPSPVKTKSK VMIDSDEDSD AEESANKRAL IDSDASDAEG
     KKRRVMLDSD DSDHEGTSKK EPTTKNLFGD DSDDDDEDRP KKTNDLDEFV EGRDEEESQE
     TSKPAYDSDD DDGPVDRHGR HFEWDFDKML AEKKAERKKK TRRGGKDGGI DIINDDDGTV
     SRLVERMKHA AKSDRNANIE RKPAFQKIKM LPEVKAIMLR AGIVEVLIEN GFMSALSEWL
     APLPDKCLPA LDIRITVLKL LHNPRFWKLD RSTLKQSGLG KAVMMLYKHP NETKENKGIA
     NKLIGEWARP IYHLDTDYST VSRQEREERD YSRMPEKRKK KINSRDEEEP NDDDQPKRPR
     IRDADEMGPT KSDDLKPGDK GYIPRARVPK PSTKDYVIRP EWRVTGAFKG EKKSTGNNRY
     DQTFRDFQER TKKSKANRIV KVSLEGRNMG I