ID   IWS1_CANAL              Reviewed;         400 AA.
AC   Q5AAR0; A0A1D8PDV4;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2017, sequence version 2.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Transcription factor IWS1;
GN   Name=IWS1; OrderedLocusNames=CAALFM_C106590CA;
GN   ORFNames=CaO19.13630, CaO19.6252;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Transcription factor involved in RNA polymerase II
CC       transcription regulation. May function in both SPT15/TBP post-
CC       recruitment and recruitment steps of transcription (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649}.
CC   -!- SIMILARITY: Belongs to the IWS1 family. {ECO:0000305}.
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DR   EMBL; CP017623; AOW26315.1; -; Genomic_DNA.
DR   RefSeq; XP_718840.2; XM_713747.2.
DR   AlphaFoldDB; Q5AAR0; -.
DR   SMR; Q5AAR0; -.
DR   STRING; 237561.Q5AAR0; -.
DR   GeneID; 3639514; -.
DR   KEGG; cal:CAALFM_C106590CA; -.
DR   CGD; CAL0000188700; orf19.13630.
DR   VEuPathDB; FungiDB:C1_06590C_A; -.
DR   eggNOG; KOG1793; Eukaryota.
DR   HOGENOM; CLU_045275_0_1_1; -.
DR   InParanoid; Q5AAR0; -.
DR   OMA; TIQFHEY; -.
DR   OrthoDB; 1461546at2759; -.
DR   PRO; PR:Q5AAR0; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR   Gene3D; 1.20.930.10; -; 1.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR017923; TFIIS_N.
DR   Pfam; PF08711; Med26; 1.
DR   PROSITE; PS51319; TFIIS_N; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..400
FT                   /note="Transcription factor IWS1"
FT                   /id="PRO_0000083355"
FT   DOMAIN          211..288
FT                   /note="TFIIS N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00649"
FT   REGION          1..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          77..149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          375..400
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..30
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..45
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..114
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..149
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   400 AA;  45797 MW;  93B9CDBEBB51E286 CRC64;
     MSDPLADYTN LSHDEIDPSS ANAAESEQAE PEQQVSEHYE PQPEELTYEN DENVLNSIKV
     QKITDAEAIG EVVRKKVIRD SRPQGYQQDD FNDNSNVTLG SRPGHQQTDE IDISSMDPQQ
     RKRFELEERM SAAIKPSNKR RRKADEDDLE RMQDDKIDYL KDQMIKAANS DVEKNSQGQI
     ATEKLKLLKE VSDILARADL AIPILDNNLL EAVRLWLEPL PDASMPAYQI QKELIHALET
     LPIKTDHLVA SGIGKVLVFY QRSKRTEPSL KKIVDRLIGD WTRPILNKSD SYKDRTVQFH
     EYNRNKFTNK LSRGVKKREA KTLYEENAER RKRAAIPSTR TTAYKIAPQV DKSLLMRQQS
     RHASNDERFK RINSKLTSMS VKRKAAKKGG PSIEGRDLAM