ID   IWS1_CANGA              Reviewed;         382 AA.
AC   Q6FVX3;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Transcription factor IWS1;
GN   Name=IWS1; OrderedLocusNames=CAGL0D04818g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Transcription factor involved in RNA polymerase II
CC       transcription regulation. May function in both SPT15/TBP post-
CC       recruitment and recruitment steps of transcription (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649}.
CC   -!- SIMILARITY: Belongs to the IWS1 family. {ECO:0000305}.
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DR   EMBL; CR380950; CAG58532.1; -; Genomic_DNA.
DR   RefSeq; XP_445621.1; XM_445621.1.
DR   AlphaFoldDB; Q6FVX3; -.
DR   SMR; Q6FVX3; -.
DR   STRING; 5478.XP_445621.1; -.
DR   EnsemblFungi; CAG58532; CAG58532; CAGL0D04818g.
DR   GeneID; 2887033; -.
DR   KEGG; cgr:CAGL0D04818g; -.
DR   CGD; CAL0128151; CAGL0D04818g.
DR   VEuPathDB; FungiDB:CAGL0D04818g; -.
DR   eggNOG; KOG1793; Eukaryota.
DR   HOGENOM; CLU_045275_0_0_1; -.
DR   InParanoid; Q6FVX3; -.
DR   OMA; VAEWTRP; -.
DR   Proteomes; UP000002428; Chromosome D.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000993; F:RNA polymerase II complex binding; IEA:EnsemblFungi.
DR   GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:EnsemblFungi.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IEA:EnsemblFungi.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR   GO; GO:0034243; P:regulation of transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   Gene3D; 1.20.930.10; -; 1.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR017923; TFIIS_N.
DR   Pfam; PF08711; Med26; 1.
DR   SUPFAM; SSF47676; SSF47676; 1.
DR   PROSITE; PS51319; TFIIS_N; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..382
FT                   /note="Transcription factor IWS1"
FT                   /id="PRO_0000083356"
FT   DOMAIN          189..266
FT                   /note="TFIIS N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00649"
FT   REGION          1..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          289..360
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        49..64
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        304..320
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        329..360
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   382 AA;  42567 MW;  2D1E9CCCD46A34D4 CRC64;
     MSDSEVKDVP VAPVEEVEAP VEAPVEAALE PSVEAPVEAP VESTVEAGEP APERTRKHIE
     SDDDDEEVQA PVEEQVTIDS SEDPKSQRQI LEDRLDRLLK KTSGRRQRAD EHDLEQYLDE
     KILRLKDEMN IAAQMDIETL NKRIEEGENK SQDKKPLVAI QKVKLLPKVM SILSKANLAD
     TILDNNLLQS VRIWLEPLPD GSLPSFEIQK SLFAALDDLP IKTEHLKESG LGRVVIFYTK
     SKRVEPQLAR LAEKLIAEWT RPIIGASDNY RDKRIMQLEF DSEKLKRKSA LDSAKRKKNK
     VSKPSSSASK GSSAQTLYEQ AAARRNRAAA PAQTTTDYKY APVSNITSVP TNARTVGVGS
     SLNNNELYKK LSSRLAKPGK RS