IWS1_CRYNJ
ID IWS1_CRYNJ Reviewed; 475 AA.
AC P0CO38; Q55WI4; Q5KJR1;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 42.
DE RecName: Full=Transcription factor IWS1;
GN Name=IWS1; OrderedLocusNames=CNC05650;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Transcription factor involved in RNA polymerase II
CC transcription regulation. May function in both SPT15/TBP post-
CC recruitment and recruitment steps of transcription (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649}.
CC -!- SIMILARITY: Belongs to the IWS1 family. {ECO:0000305}.
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DR EMBL; AE017343; AAW42473.1; -; Genomic_DNA.
DR RefSeq; XP_569780.1; XM_569780.1.
DR AlphaFoldDB; P0CO38; -.
DR SMR; P0CO38; -.
DR STRING; 5207.AAW42473; -.
DR PaxDb; P0CO38; -.
DR EnsemblFungi; AAW42473; AAW42473; CNC05650.
DR GeneID; 3256341; -.
DR KEGG; cne:CNC05650; -.
DR VEuPathDB; FungiDB:CNC05650; -.
DR eggNOG; KOG1793; Eukaryota.
DR HOGENOM; CLU_045275_2_2_1; -.
DR InParanoid; P0CO38; -.
DR OMA; QWCISEG; -.
DR OrthoDB; 977077at2759; -.
DR Proteomes; UP000002149; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR Gene3D; 1.20.930.10; -; 1.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR Pfam; PF08711; Med26; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..475
FT /note="Transcription factor IWS1"
FT /id="PRO_0000083357"
FT DOMAIN 290..367
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00649"
FT REGION 1..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..55
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 475 AA; 54385 MW; 28B5C2BA3DED8109 CRC64;
MSSPALDTIH DQTGEQDLHQ EVQAQEHLPV EPTPEVQEEP ESDHQDDDEQ PEAQVLEQEQ
EQVAEQERLQ DQEDQDQGAE LVSQQPTAEE QEETRDELYN EVFGNQGSEA SDLSDDEDVR
MDEGEKYVPA TATSAAKIPK FKKSKRDDED EDEDEDEDED DGGERRRKKK KRAERRRQRQ
EEEDEDEAPV LDEATQRRLA LEERIDAIGK KPKAIRRKKK GDDDVDIVDS YHDDICARLR
DRMIAAADKD EAANRIKMPG TAKLAMLDEV MGVLRNTTLW QSIVDNGVLE AVKRWLEPLP
DKSLPSVGIQ KAIFEVLPKM DLDTTTLKEC RLGPIVLFYT KTKRVTPAIN RQADALVQAW
SRPIIKRPAN YRSRYIESQN EVEQSQGGGG TGGGYSQSQR GPGERKFKRF DVKKALEENA
HRKGARLQIV QDVQYTVAPE PKTHHHAEEM QHVSRIQQDN KKFNRFARQV KTKKH