ID   IWS1_DEBHA              Reviewed;         404 AA.
AC   Q6BQ49;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Transcription factor IWS1;
GN   Name=IWS1; OrderedLocusNames=DEHA2E08360g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Transcription factor involved in RNA polymerase II
CC       transcription regulation. May function in both SPT15/TBP post-
CC       recruitment and recruitment steps of transcription (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649}.
CC   -!- SIMILARITY: Belongs to the IWS1 family. {ECO:0000305}.
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DR   EMBL; CR382137; CAG87905.2; -; Genomic_DNA.
DR   RefSeq; XP_459671.2; XM_459671.1.
DR   AlphaFoldDB; Q6BQ49; -.
DR   SMR; Q6BQ49; -.
DR   STRING; 4959.XP_459671.2; -.
DR   PRIDE; Q6BQ49; -.
DR   EnsemblFungi; CAG87905; CAG87905; DEHA2E08360g.
DR   GeneID; 2902270; -.
DR   KEGG; dha:DEHA2E08360g; -.
DR   VEuPathDB; FungiDB:DEHA2E08360g; -.
DR   eggNOG; KOG1793; Eukaryota.
DR   HOGENOM; CLU_045275_0_1_1; -.
DR   InParanoid; Q6BQ49; -.
DR   OMA; TIQFHEY; -.
DR   OrthoDB; 1461546at2759; -.
DR   Proteomes; UP000000599; Chromosome E.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.930.10; -; 1.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR017923; TFIIS_N.
DR   Pfam; PF08711; Med26; 1.
DR   PROSITE; PS51319; TFIIS_N; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..404
FT                   /note="Transcription factor IWS1"
FT                   /id="PRO_0000083358"
FT   DOMAIN          212..289
FT                   /note="TFIIS N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00649"
FT   REGION          1..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          313..343
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          382..404
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..41
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        42..56
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        317..339
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   404 AA;  46512 MW;  527B9CFAEC988A61 CRC64;
     MSDKEGETAL YNDREEEARQ FFSDSAEPQS QGGSNELAVN ENEDNNNDEV EDDADENIYS
     IQAHKITGDE ENNREVTMKK NVRKAKKYDE FKNERDEQGF VPMGENPEYG GMDYSNEDPQ
     ARKRRLLEEK MESAIKSKTS RRRRADEDDL ERMQDDRIDF LKDQMIKAAN LDVEKNSQGQ
     IATEKLKLLN EVVDILSKAD LAISILDNNL LEAVRLWLEP LPDASMPAYQ IQKELIHSLT
     VLPIKTDHLI ASGIGKVLVY YQRSKRTEAN LKKVVDRLIG DWTRPILNKS DSYKDRTIQF
     NEYNKNRFTN QLSSARRSKP KEAKSLYEES AERRKRAAIP AARTTAYKIA PKVDPSLLRR
     QQLNSNGNND ERFKRINQKL TSMNFKKKSS KKSGPSIEGR NLTI