ID   IWS1_XENTR              Reviewed;         909 AA.
AC   Q505H7;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Protein IWS1 homolog;
DE   AltName: Full=IWS1-like protein;
GN   Name=iws1; Synonyms=iws1l;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor which plays a key role in defining the
CC       composition of the RNA polymerase II (RNAPII) elongation complex and in
CC       modulating the production of mature mRNA transcripts. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649}.
CC   -!- SIMILARITY: Belongs to the IWS1 family. {ECO:0000305}.
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DR   EMBL; BC094537; AAH94537.1; -; mRNA.
DR   RefSeq; NP_001025690.1; NM_001030519.1.
DR   AlphaFoldDB; Q505H7; -.
DR   SMR; Q505H7; -.
DR   STRING; 8364.ENSXETP00000006464; -.
DR   PaxDb; Q505H7; -.
DR   PRIDE; Q505H7; -.
DR   DNASU; 595082; -.
DR   GeneID; 595082; -.
DR   KEGG; xtr:595082; -.
DR   CTD; 55677; -.
DR   Xenbase; XB-GENE-6458249; iws1.
DR   eggNOG; KOG1793; Eukaryota.
DR   HOGENOM; CLU_018182_0_0_1; -.
DR   InParanoid; Q505H7; -.
DR   OMA; AFDEYME; -.
DR   OrthoDB; 380765at2759; -.
DR   PhylomeDB; Q505H7; -.
DR   TreeFam; TF315504; -.
DR   Reactome; R-XTR-674695; RNA Polymerase II Pre-transcription Events.
DR   Reactome; R-XTR-75955; RNA Polymerase II Transcription Elongation.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.930.10; -; 1.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR017923; TFIIS_N.
DR   Pfam; PF08711; Med26; 1.
DR   SUPFAM; SSF47676; SSF47676; 1.
DR   PROSITE; PS51319; TFIIS_N; 1.
PE   2: Evidence at transcript level;
KW   mRNA processing; mRNA splicing; mRNA transport; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation;
KW   Transport.
FT   CHAIN           1..909
FT                   /note="Protein IWS1 homolog"
FT                   /id="PRO_0000083350"
FT   REPEAT          451..470
FT                   /note="1"
FT   REPEAT          511..530
FT                   /note="2"
FT   DOMAIN          704..782
FT                   /note="TFIIS N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00649"
FT   REGION          1..615
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          451..530
FT                   /note="2 X approximate repeats"
FT   REGION          786..820
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..318
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        319..333
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        334..396
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        409..435
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        442..549
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        560..577
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        581..596
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        597..615
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        788..804
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   909 AA;  100190 MW;  6957858D97AF69CC CRC64;
     MEADYYSPEH SDADDGGATP VQDERDSASD DEGNEREQRS EPGSPERQSE DEHSDIEDNK
     HRSDSGSDNE EGAEHNDSED EHRPHNSSDL ENHDASDSEN EESRNHIASD SEDDVRRQKG
     SDSEGSPVKD AASDSDEEPI RHSASDSEDD GPRKEQANDS EDERHKKNTA SDSEDEAPAK
     HQGSDSEDEA PAKHVASDSE DEAPAKRAAS DSEDEAPAKR AASDSEDEAP AKRAASDSED
     EAPAKRAASD SEDEAPAKRA ASDSEDEAPP KRAASDSEDE APPKRAASDS EDEAPPKRAA
     SDSEDEAPAK RKVSSSEDEA PSKQAFSASK KSSKKSSGDS EDKARGKRAI IDSDDEDEDV
     PVKRAASDSE EETHPKGKAS DSEDEAPSKQ QPSDSEEETP AKAAANNSED EFPRMKRKIV
     SSDDSDDEID RKPLQKKKKK SPRRSSESDS SDKVDSKKRK ASESDEEEEK ASKKKSAILS
     DSEDEDAANK SGNKKSRILS DGDDSDSDAG SDRPKQKKKL ASSDSEEEDE LKSKTEAKNA
     DKLFGSESDS GNEEENLIAD IFGESGDEEE EEFTGFNQED LEGEKTVTSA NKQHAAAADS
     DSDDDDVKPG KMGDFKSDFE IMLERKKSMS GKRRRNRDGG TFISDADDVV NAMIMKMNEA
     AEEDRNLNSS KKPALKKLTL LPTVVMHLKK QDLKETFIDS GVMSAIKEWL TPLPDRSLPA
     LKIREELLKI LQELPSVSQE TLKHSGIGRA VMYLYKHPKE SRPNKDIAGK LINEWSRPIF
     GLTSNYKGMT REEREQRDLE QMPQRRRMSS SGGQTPRRDL EKVLTGEEKA LRPGDPGFCA
     RARVPLPSNK DYVVRPKWNV EMESARYQGS SKKGVSRLDK QMRKFVDIKK KNRFGHAVKI
     SIEGNKMPL