ID   IWS1_YARLI              Reviewed;         414 AA.
AC   Q6CGB2;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Transcription factor IWS1;
GN   Name=IWS1; OrderedLocusNames=YALI0A20724g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Transcription factor involved in RNA polymerase II
CC       transcription regulation. May function in both SPT15/TBP post-
CC       recruitment and recruitment steps of transcription (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649}.
CC   -!- SIMILARITY: Belongs to the IWS1 family. {ECO:0000305}.
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DR   EMBL; CR382127; CAG84238.1; -; Genomic_DNA.
DR   RefSeq; XP_500300.1; XM_500300.1.
DR   AlphaFoldDB; Q6CGB2; -.
DR   SMR; Q6CGB2; -.
DR   STRING; 4952.CAG84238; -.
DR   EnsemblFungi; CAG84238; CAG84238; YALI0_A20724g.
DR   GeneID; 2905784; -.
DR   KEGG; yli:YALI0A20724g; -.
DR   VEuPathDB; FungiDB:YALI0_A20724g; -.
DR   HOGENOM; CLU_045275_0_0_1; -.
DR   InParanoid; Q6CGB2; -.
DR   OMA; TIQFHEY; -.
DR   Proteomes; UP000001300; Chromosome A.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central.
DR   Gene3D; 1.20.930.10; -; 1.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR017923; TFIIS_N.
DR   Pfam; PF08711; Med26; 1.
DR   PROSITE; PS51319; TFIIS_N; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..414
FT                   /note="Transcription factor IWS1"
FT                   /id="PRO_0000083365"
FT   DOMAIN          228..305
FT                   /note="TFIIS N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00649"
FT   REGION          1..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          395..414
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..46
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..84
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..112
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..138
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   414 AA;  46235 MW;  1575721C65E7D43A CRC64;
     MSDTEKPIKS EEPVDEGVDR VDEEENVEEP AEDVGEAAEE ASEAPEEAPA EAATTTEAAP
     ADDDEDDSDL SDLDEDEIKN AAIEDDDDDY NKLSAHRRKV QSSGKKTLKK RATKDSRAAD
     DDEDEIDHSH IDLDPSMARR REIEARIDAA MKPASQRRKK LGEDDIEMMQ DERISNLREK
     MRNAAIADAE SNREGQPATH KLQLLPEVKD VLQKHHLADS ILDNNLLEAV RIWLEPLPDA
     SLPSYSIQEE LFDALVRLPI KSIHLRESGL GKVVTFYRKS KQPQLRIKRI ADKLVADWTR
     PIMGRSDNYR EKVVSTRSFD PSTQEIALAV AAKRAQTLKD GTLAEKQAER RRRAHIPSAQ
     PANYRVAPKS EIIPQNRGGS TNDMTFKRLK GKLGVTKTGK KKSGVSIEGR GLNG