ID   IXO39_IXOSC             Reviewed;          60 AA.
AC   Q4PMW1;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 15.
DE   RecName: Full=Ixodegrin YY-39 {ECO:0000303|PubMed:25152502};
DE   AltName: Full=Platelet aggregation inhibitor {ECO:0000305};
DE            Short=PAI {ECO:0000305};
DE   AltName: Full=Tick anti-thrombosis peptide {ECO:0000303|PubMed:25152502};
DE   Flags: Precursor;
OS   Ixodes scapularis (Black-legged tick) (Deer tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=6945;
RN   [1] {ECO:0000312|EMBL:AAY66649.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Is-all-979; TISSUE=Salivary gland;
RA   Tseng H.-P., Hseu T.-H., Buhler D.R., Wang W.-D., Tsai H.-L., Hu C.-H.;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:AAY66649.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Is-all-979; TISSUE=Salivary gland;
RX   PubMed=16431279; DOI=10.1016/j.ibmb.2005.11.005;
RA   Ribeiro J.M.C., Alarcon-Chaidez F., Francischetti I.M.B., Mans B.J.,
RA   Mather T.N., Valenzuela J.G., Wikel S.K.;
RT   "An annotated catalog of salivary gland transcripts from Ixodes scapularis
RT   ticks.";
RL   Insect Biochem. Mol. Biol. 36:111-129(2006).
RN   [3]
RP   FUNCTION, AND SYNTHESIS OF 22-60.
RX   PubMed=25152502; DOI=10.1016/j.peptides.2014.08.008;
RA   Tang J., Fang Y., Han Y., Bai X., Yan X., Zhang Y., Lai R., Zhang Z.;
RT   "YY-39, a tick anti-thrombosis peptide containing RGD domain.";
RL   Peptides 68:99-104(2015).
CC   -!- FUNCTION: Tick salivary platelet aggregation inhibitor that plays an
CC       important part in the anti-hemostatic strategy of ticks (Probable).
CC       Inhibits platelet aggregation induced by ADP, thrombin and thromboxane
CC       A2 (TXA2) (PubMed:25152502). Blocks platelet adhesion to soluble
CC       collagen (most probably through the binding to alpha-2/beta-1 integrin
CC       (ITGA2/ITGB1)) and binds to purified glycoprotein IIb/IIIa
CC       (ITGA2B/ITGB3) in a dose-dependent manner (PubMed:25152502). In vivo,
CC       reduces thrombus weight effectively in a rat arteriovenous shunt model
CC       and inhibits thrombosis in a carrageenan-induced mouse tail thrombosis
CC       model (PubMed:25152502). {ECO:0000269|PubMed:25152502, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in salivary glands.
CC       {ECO:0000305|PubMed:16431279}.
CC   -!- PTM: Contains 3 disulfide bonds. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ixodegrin family. {ECO:0000305}.
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DR   EMBL; DQ066012; AAY66649.1; -; mRNA.
DR   Proteomes; UP000001555; Unplaced.
PE   3: Inferred from homology;
KW   Disulfide bond; Hemostasis impairing toxin;
KW   Platelet aggregation inhibiting toxin; Reference proteome; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..60
FT                   /note="Ixodegrin YY-39"
FT                   /id="PRO_5004241823"
FT   MOTIF           49..51
FT                   /note="Cell attachment site"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   60 AA;  6460 MW;  F8BF5C76FBD53492 CRC64;
     MNAALIAALL ILGALTLDAT AYSSTCERIP CTNNSDCHGP DLCQCRPPRG DDFGYFCSEY