ID   IXOSB_IXOSI             Reviewed;          89 AA.
AC   A7UDM9;
DT   13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=Ixosin-B {ECO:0000303|PubMed:18295522};
DE   Flags: Precursor;
OS   Ixodes sinensis (Hard tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=339422;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:ABU24471.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 58-89, FUNCTION, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Salivary gland {ECO:0000269|PubMed:18295522};
RX   PubMed=18295522; DOI=10.1016/j.cbpb.2007.10.002;
RA   Liu Z., Liu H., Liu X., Wu X.;
RT   "Purification and cloning of a novel antimicrobial peptide from salivary
RT   glands of the hard tick, Ixodes sinensis.";
RL   Comp. Biochem. Physiol. 149:557-561(2008).
CC   -!- FUNCTION: Has antifungal activity against C.albicans. Has antibacterial
CC       activity against the Gram-positive bacterium S.aureus and the Gram-
CC       negative bacterium E.coli. Lacks hemolytic activity against rabbit
CC       erythrocytes. {ECO:0000269|PubMed:18295522}.
CC   -!- MASS SPECTROMETRY: Mass=3814.5; Method=FAB;
CC       Evidence={ECO:0000269|PubMed:18295522};
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DR   EMBL; EU047746; ABU24471.1; -; mRNA.
DR   AlphaFoldDB; A7UDM9; -.
DR   GO; GO:0050832; P:defense response to fungus; IDA:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Fungicide; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   PROPEP          27..57
FT                   /evidence="ECO:0000255, ECO:0000269|PubMed:18295522"
FT                   /id="PRO_0000386443"
FT   PEPTIDE         58..89
FT                   /note="Ixosin-B"
FT                   /evidence="ECO:0000269|PubMed:18295522"
FT                   /id="PRO_0000386444"
FT   REGION          68..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   89 AA;  9565 MW;  5FB7FB74FEF0811D CRC64;
     MASGWTHRLL LLAAVVTLGA TPIAAASMEY LVTAPGYLTP NADIKITAVV TNPSSAGQLK
     VDLWGTRSGI QPEQHSSGKS DVRRWRSRY