ID   IXOSN_IXOSI             Reviewed;          79 AA.
AC   Q2LKX9;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=Ixosin;
DE   Flags: Precursor;
OS   Ixodes sinensis (Hard tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=339422;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAZ57202.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 57-79, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Salivary gland {ECO:0000269|PubMed:16087274};
RX   PubMed=16087274; DOI=10.1016/j.peptides.2005.06.020;
RA   Yu D., Sheng Z., Xu X., Li J., Yang H., Liu Z., Rees H.H., Lai R.;
RT   "A novel antimicrobial peptide from salivary glands of the hard tick,
RT   Ixodes sinensis.";
RL   Peptides 27:31-35(2006).
CC   -!- FUNCTION: Has antifungal activity against C.albicans. Has antibacterial
CC       activity against the Gram-positive bacterium S.aureus and the Gram-
CC       negative bacterium E.coli. Lacks hemolytic activity against rabbit
CC       erythrocytes. {ECO:0000269|PubMed:16087274}.
CC   -!- MASS SPECTROMETRY: Mass=2870.5; Method=FAB;
CC       Evidence={ECO:0000269|PubMed:16087274};
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DR   EMBL; DQ100462; AAZ57202.1; -; mRNA.
DR   AlphaFoldDB; Q2LKX9; -.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Fungicide.
FT   PROPEP          1..56
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000269|PubMed:16087274"
FT                   /id="PRO_0000245156"
FT   PEPTIDE         57..79
FT                   /note="Ixosin"
FT                   /evidence="ECO:0000269|PubMed:16087274"
FT                   /id="PRO_0000245157"
SQ   SEQUENCE   79 AA;  8866 MW;  47AD8A78403A4D9E CRC64;
     MSAHKVQIGL SSGQFRVALQ VPSVRLKGLG SFHTGSIVLP SQGSLREDQI SLHNQDGLHK
     VMREVLGYER NSYKKFFLR