ID   IZH1_ASHGO              Reviewed;         317 AA.
AC   Q753H5;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=ADIPOR-like receptor IZH1;
GN   Name=IZH1; OrderedLocusNames=AFR337W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: ADIPOR-like receptor involved in zinc metabolism either by
CC       altering membrane sterol content or by directly altering cellular zinc
CC       levels. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
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DR   EMBL; AE016819; AAS53708.1; -; Genomic_DNA.
DR   RefSeq; NP_985884.1; NM_211239.1.
DR   AlphaFoldDB; Q753H5; -.
DR   SMR; Q753H5; -.
DR   STRING; 33169.AAS53708; -.
DR   EnsemblFungi; AAS53708; AAS53708; AGOS_AFR337W.
DR   GeneID; 4622151; -.
DR   KEGG; ago:AGOS_AFR337W; -.
DR   eggNOG; KOG0748; Eukaryota.
DR   HOGENOM; CLU_023075_2_0_1; -.
DR   InParanoid; Q753H5; -.
DR   OMA; GYEMAMG; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR   InterPro; IPR004254; AdipoR/HlyIII-related.
DR   PANTHER; PTHR20855; PTHR20855; 1.
DR   Pfam; PF03006; HlyIII; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..317
FT                   /note="ADIPOR-like receptor IZH1"
FT                   /id="PRO_0000240372"
FT   TOPO_DOM        1..80
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..113
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        114..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        137..148
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        170..175
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        197..210
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        232..243
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        265..283
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        284..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        305..317
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        73
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        197
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   317 AA;  35981 MW;  A1EA7C9636B710E0 CRC64;
     MSEERGMKEQ TISEMAQEMA HTTSEGLKKR IRKLYTFDEL PAWQKDNELI LSGYVRETNS
     VKECLRAMTY FNNESINIYT HLIPGVAYLV LFLIFADLVL AQLLPGLDAG EHRMLRFYLL
     GAFTCLACSS CFHCLKQHSE PHSRLWSKVD YLGILAQITC STISLLYYGY HSYPSHFVFF
     STLTVALCSA CAVLVLNDSF NTVAFRPLRA FLFMAFGLSG VIPVLAGSYQ FGFAEWAARI
     QLKYVLYEAV FYITGALVYG FRIPERFAPG KFDMVGHSHQ IFHLLVVLGT LCHFRAVTGS
     YIFICTGKHY SSLLMFI