IZH1_YEAST
ID IZH1_YEAST Reviewed; 316 AA.
AC Q03419; D6VTB4; Q6Q557;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=ADIPOR-like receptor IZH1;
DE AltName: Full=Implicated in zinc homeostasis protein 1;
GN Name=IZH1; OrderedLocusNames=YDR492W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP INDUCTION.
RX PubMed=10884426; DOI=10.1073/pnas.97.14.7957;
RA Lyons T.J., Gasch A.P., Gaither L.A., Botstein D., Brown P.O., Eide D.J.;
RT "Genome-wide characterization of the Zap1p zinc-responsive regulon in
RT yeast.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:7957-7962(2000).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [6]
RP FUNCTION, AND INDUCTION.
RX PubMed=15060275; DOI=10.1073/pnas.0306324101;
RA Lyons T.J., Villa N.Y., Regalla L.M., Kupchak B.R., Vagstad A., Eide D.J.;
RT "Metalloregulation of yeast membrane steroid receptor homologs.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:5506-5511(2004).
CC -!- FUNCTION: ADIPOR-like receptor involved in zinc metabolism either by
CC altering membrane sterol content or by directly altering cellular zinc
CC levels. {ECO:0000269|PubMed:15060275}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- INDUCTION: Expression is regulated by the zinc metabolism transcription
CC factor ZAP1 via its promoter ZRE element (zinc-responsive element).
CC {ECO:0000269|PubMed:10884426, ECO:0000269|PubMed:15060275}.
CC -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
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DR EMBL; U33050; AAB64908.1; -; Genomic_DNA.
DR EMBL; AY558493; AAS56819.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA12324.1; -; Genomic_DNA.
DR PIR; S69659; S69659.
DR RefSeq; NP_010780.1; NM_001180800.1.
DR AlphaFoldDB; Q03419; -.
DR SMR; Q03419; -.
DR BioGRID; 32543; 76.
DR DIP; DIP-8787N; -.
DR STRING; 4932.YDR492W; -.
DR PaxDb; Q03419; -.
DR PRIDE; Q03419; -.
DR EnsemblFungi; YDR492W_mRNA; YDR492W; YDR492W.
DR GeneID; 852102; -.
DR KEGG; sce:YDR492W; -.
DR SGD; S000002900; IZH1.
DR VEuPathDB; FungiDB:YDR492W; -.
DR eggNOG; KOG0748; Eukaryota.
DR GeneTree; ENSGT00940000170813; -.
DR HOGENOM; CLU_023075_2_0_1; -.
DR InParanoid; Q03419; -.
DR OMA; LRKGHMP; -.
DR BioCyc; YEAST:G3O-30015-MON; -.
DR PRO; PR:Q03419; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; Q03419; protein.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:SGD.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IMP:SGD.
DR InterPro; IPR004254; AdipoR/HlyIII-related.
DR PANTHER; PTHR20855; PTHR20855; 1.
DR Pfam; PF03006; HlyIII; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..316
FT /note="ADIPOR-like receptor IZH1"
FT /id="PRO_0000240373"
FT TOPO_DOM 1..89
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..117
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..156
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..181
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..218
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 240..245
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 267..279
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 301..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT CARBOHYD 79
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 207
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 139
FT /note="H -> R (in Ref. 3; AAS56819)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 316 AA; 36492 MW; 624DDC238B0A784F CRC64;
MSITTTRRRN QDSVCCKATR ASIKVEAVSG QTVFEKQKLL HNFDELPEWQ KDNDKILTGY
VRETLSWKKC LYSLFYWNNE TVNIYTHLVP AIVYFVFAIT LTNYFLIPVF PSTSWSDYTV
INIFLMGAFS CLMCSSCFHC MKQHSEKQSN FWSKLDYLGI ISLISCSMIP IIYFGYFDHI
SYFSLFTIVT LVLATFCTVC VLHDKFNTST FRPFRAMFFI LFGFSGLLPL TTGFFKFGIQ
GVLNRIKVSF VFWEALFYIS GAVIYGFRIP ETLAPGKFDF FGSSHQIFHI MVVLGSVCHL
KAIIDSYKLM HSHIHP
