IZH3_YEAST
ID IZH3_YEAST Reviewed; 543 AA.
AC Q07959; D6VY25;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=ADIPOR-like receptor IZH3;
DE AltName: Full=Implicated in zinc homeostasis protein 3;
GN Name=IZH3; OrderedLocusNames=YLR023C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [4]
RP FUNCTION.
RX PubMed=15060275; DOI=10.1073/pnas.0306324101;
RA Lyons T.J., Villa N.Y., Regalla L.M., Kupchak B.R., Vagstad A., Eide D.J.;
RT "Metalloregulation of yeast membrane steroid receptor homologs.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:5506-5511(2004).
CC -!- FUNCTION: ADIPOR-like receptor involved in zinc metabolism either by
CC altering membrane sterol content or by directly altering cellular zinc
CC levels. {ECO:0000269|PubMed:15060275}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z73195; CAA97546.1; -; Genomic_DNA.
DR EMBL; BK006945; DAA09341.1; -; Genomic_DNA.
DR PIR; S64850; S64850.
DR RefSeq; NP_013123.1; NM_001181910.1.
DR AlphaFoldDB; Q07959; -.
DR SMR; Q07959; -.
DR BioGRID; 31297; 108.
DR IntAct; Q07959; 1.
DR MINT; Q07959; -.
DR STRING; 4932.YLR023C; -.
DR MaxQB; Q07959; -.
DR PaxDb; Q07959; -.
DR PRIDE; Q07959; -.
DR EnsemblFungi; YLR023C_mRNA; YLR023C; YLR023C.
DR GeneID; 850710; -.
DR KEGG; sce:YLR023C; -.
DR SGD; S000004013; IZH3.
DR VEuPathDB; FungiDB:YLR023C; -.
DR eggNOG; KOG0748; Eukaryota.
DR HOGENOM; CLU_025943_0_1_1; -.
DR InParanoid; Q07959; -.
DR OMA; GHYRAIL; -.
DR BioCyc; YEAST:G3O-32184-MON; -.
DR PRO; PR:Q07959; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; Q07959; protein.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:SGD.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IMP:SGD.
DR InterPro; IPR004254; AdipoR/HlyIII-related.
DR PANTHER; PTHR20855; PTHR20855; 1.
DR Pfam; PF03006; HlyIII; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..543
FT /note="ADIPOR-like receptor IZH3"
FT /id="PRO_0000240375"
FT TOPO_DOM 1..259
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..295
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 317..330
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..353
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 354..357
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 358..378
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 379..395
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 396..416
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 417..425
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 426..446
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 447..505
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 506..526
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 527..543
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 123
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 153
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 256
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 319
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 543 AA; 62571 MW; D7417F9D4C9F8BBD CRC64;
MMDSSSKSLT QYIPSPMGSL SRLKQKGVDN FQKVKKSGKS IYNYNYSKFV PHPFSTIDES
VKHSESGRYD DLEIIRPTKE KEVTSSVYKR NSGKSLNTES QFSLGDSDAA TLVNSVATFK
LNNASTSTSL VSSSSTVCSQ AKSSLRSPTS RLNDTKIKEE NNYISSVKDY CGPMRKSMVK
TEILIEEPLN PTTDIKSFIN SYNHGKAYSL GETQHLHYYQ LPFPWRENRY IIHGYRFYNT
HSKSLLSIFN WYGWHNETSN IWSHLLGAIY IIYLAIYDFP QSEVWRNSQV PPQARWIVFM
FLAAALKCML SSVFWHTFNG TSFLKLRSKF ACVDYSGITI LITASILTTE FVTMYSCYWA
MYTYMSISLA LGVFGVFMNW SPRFDRPEAR PLRIRFFILL ATMGVLSFLH LIFLTDLHYA
ATLFSPVTYK SVVWYLVGVV FYGSFIPERF RSDVQVDKTI PTNYELSTDL EIITKQREIH
FREVPTAHSK CSSCPSHAKS FKSLWWVDYF GCSHTFWHFF VVLGVIGHYR AILDMFAKRW
ILS