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IZH3_YEAST
ID   IZH3_YEAST              Reviewed;         543 AA.
AC   Q07959; D6VY25;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=ADIPOR-like receptor IZH3;
DE   AltName: Full=Implicated in zinc homeostasis protein 3;
GN   Name=IZH3; OrderedLocusNames=YLR023C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169871;
RA   Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA   Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA   Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA   Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA   Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA   Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA   Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA   Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA   Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA   Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA   Zollner A., Hani J., Hoheisel J.D.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL   Nature 387:87-90(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [4]
RP   FUNCTION.
RX   PubMed=15060275; DOI=10.1073/pnas.0306324101;
RA   Lyons T.J., Villa N.Y., Regalla L.M., Kupchak B.R., Vagstad A., Eide D.J.;
RT   "Metalloregulation of yeast membrane steroid receptor homologs.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:5506-5511(2004).
CC   -!- FUNCTION: ADIPOR-like receptor involved in zinc metabolism either by
CC       altering membrane sterol content or by directly altering cellular zinc
CC       levels. {ECO:0000269|PubMed:15060275}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC       Multi-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
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DR   EMBL; Z73195; CAA97546.1; -; Genomic_DNA.
DR   EMBL; BK006945; DAA09341.1; -; Genomic_DNA.
DR   PIR; S64850; S64850.
DR   RefSeq; NP_013123.1; NM_001181910.1.
DR   AlphaFoldDB; Q07959; -.
DR   SMR; Q07959; -.
DR   BioGRID; 31297; 108.
DR   IntAct; Q07959; 1.
DR   MINT; Q07959; -.
DR   STRING; 4932.YLR023C; -.
DR   MaxQB; Q07959; -.
DR   PaxDb; Q07959; -.
DR   PRIDE; Q07959; -.
DR   EnsemblFungi; YLR023C_mRNA; YLR023C; YLR023C.
DR   GeneID; 850710; -.
DR   KEGG; sce:YLR023C; -.
DR   SGD; S000004013; IZH3.
DR   VEuPathDB; FungiDB:YLR023C; -.
DR   eggNOG; KOG0748; Eukaryota.
DR   HOGENOM; CLU_025943_0_1_1; -.
DR   InParanoid; Q07959; -.
DR   OMA; GHYRAIL; -.
DR   BioCyc; YEAST:G3O-32184-MON; -.
DR   PRO; PR:Q07959; -.
DR   Proteomes; UP000002311; Chromosome XII.
DR   RNAct; Q07959; protein.
DR   GO; GO:0005783; C:endoplasmic reticulum; HDA:SGD.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0006882; P:cellular zinc ion homeostasis; IMP:SGD.
DR   InterPro; IPR004254; AdipoR/HlyIII-related.
DR   PANTHER; PTHR20855; PTHR20855; 1.
DR   Pfam; PF03006; HlyIII; 1.
PE   1: Evidence at protein level;
KW   Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..543
FT                   /note="ADIPOR-like receptor IZH3"
FT                   /id="PRO_0000240375"
FT   TOPO_DOM        1..259
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        281..295
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        296..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        317..330
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        331..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        354..357
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        379..395
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        396..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        417..425
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        426..446
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        447..505
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        506..526
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        527..543
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        45
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        123
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        153
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        256
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        319
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   543 AA;  62571 MW;  D7417F9D4C9F8BBD CRC64;
     MMDSSSKSLT QYIPSPMGSL SRLKQKGVDN FQKVKKSGKS IYNYNYSKFV PHPFSTIDES
     VKHSESGRYD DLEIIRPTKE KEVTSSVYKR NSGKSLNTES QFSLGDSDAA TLVNSVATFK
     LNNASTSTSL VSSSSTVCSQ AKSSLRSPTS RLNDTKIKEE NNYISSVKDY CGPMRKSMVK
     TEILIEEPLN PTTDIKSFIN SYNHGKAYSL GETQHLHYYQ LPFPWRENRY IIHGYRFYNT
     HSKSLLSIFN WYGWHNETSN IWSHLLGAIY IIYLAIYDFP QSEVWRNSQV PPQARWIVFM
     FLAAALKCML SSVFWHTFNG TSFLKLRSKF ACVDYSGITI LITASILTTE FVTMYSCYWA
     MYTYMSISLA LGVFGVFMNW SPRFDRPEAR PLRIRFFILL ATMGVLSFLH LIFLTDLHYA
     ATLFSPVTYK SVVWYLVGVV FYGSFIPERF RSDVQVDKTI PTNYELSTDL EIITKQREIH
     FREVPTAHSK CSSCPSHAKS FKSLWWVDYF GCSHTFWHFF VVLGVIGHYR AILDMFAKRW
     ILS
 
 
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