ID   IZUM3_BOVIN             Reviewed;         240 AA.
AC   A6QL94;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Izumo sperm-egg fusion protein 3;
DE   Flags: Precursor;
GN   Name=IZUMO3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Monomer and homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Izumo is the name of a Japanese shrine to marriage.
CC   -!- SIMILARITY: Belongs to the Izumo family. {ECO:0000305}.
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DR   EMBL; BC147884; AAI47885.1; -; mRNA.
DR   RefSeq; NP_001099112.1; NM_001105642.1.
DR   AlphaFoldDB; A6QL94; -.
DR   SMR; A6QL94; -.
DR   STRING; 9913.ENSBTAP00000031847; -.
DR   PaxDb; A6QL94; -.
DR   PRIDE; A6QL94; -.
DR   Ensembl; ENSBTAT00000031901; ENSBTAP00000031847; ENSBTAG00000023412.
DR   GeneID; 786878; -.
DR   KEGG; bta:786878; -.
DR   CTD; 100129669; -.
DR   VEuPathDB; HostDB:ENSBTAG00000023412; -.
DR   VGNC; VGNC:30356; IZUMO3.
DR   eggNOG; ENOG502S8ID; Eukaryota.
DR   GeneTree; ENSGT00390000017601; -.
DR   HOGENOM; CLU_103188_0_0_1; -.
DR   InParanoid; A6QL94; -.
DR   OMA; SEDCIVT; -.
DR   OrthoDB; 1563154at2759; -.
DR   TreeFam; TF339468; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000023412; Expressed in semen and 9 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   InterPro; IPR029389; IZUMO.
DR   Pfam; PF15005; IZUMO; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..240
FT                   /note="Izumo sperm-egg fusion protein 3"
FT                   /id="PRO_0000342456"
FT   TOPO_DOM        23..176
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        198..240
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   240 AA;  27841 MW;  F636EDA23CC050AF CRC64;
     MGDLWLLLLL PLSLAAFHGV KGCLECDPKF IEEVKSLLGK LVPPEVPGRT HMLERQMKEM
     IRLSFKVSHR DKMLRVLAVQ KVVDLRTWLK IELDKLSKEK WKGVFILQGR LLDIRKNLDS
     KLEKLLKKFS EVACSEDCVV TEGPILDCWT CLRITSRCFR GEYCEEDDPK KAESREIGLF
     LILLAEGVIL GGVLLLFHFC ISHQRKMKAI RRSLKTYLEK KLEELMGIKD EKEKDFRGRE