IZUM3_HUMAN
ID IZUM3_HUMAN Reviewed; 239 AA.
AC Q5VZ72;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 4.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Izumo sperm-egg fusion protein 3;
DE Flags: Precursor;
GN Name=IZUMO3; Synonyms=C9orf134;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
CC -!- SUBUNIT: Monomer and homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Izumo is the name of a Japanese shrine to marriage.
CC -!- SIMILARITY: Belongs to the Izumo family. {ECO:0000305}.
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DR EMBL; AL162232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005251389.1; XM_005251332.3.
DR AlphaFoldDB; Q5VZ72; -.
DR STRING; 9606.ENSP00000474246; -.
DR TCDB; 8.A.55.2.2; the izumo sperm-egg fusion protein 1 (izumo1) family.
DR GlyGen; Q5VZ72; 2 sites.
DR BioMuta; IZUMO3; -.
DR DMDM; 238054395; -.
DR MassIVE; Q5VZ72; -.
DR PaxDb; Q5VZ72; -.
DR PeptideAtlas; Q5VZ72; -.
DR PRIDE; Q5VZ72; -.
DR ProteomicsDB; 65675; -.
DR Antibodypedia; 49567; 1 antibodies from 1 providers.
DR Ensembl; ENST00000543880.7; ENSP00000438895.1; ENSG00000205442.13.
DR MANE-Select; ENST00000543880.7; ENSP00000438895.1; NM_001365008.2; NP_001351937.1.
DR UCSC; uc064sla.1; human.
DR GeneCards; IZUMO3; -.
DR HGNC; HGNC:31421; IZUMO3.
DR HPA; ENSG00000205442; Tissue enriched (testis).
DR MIM; 618896; gene.
DR neXtProt; NX_Q5VZ72; -.
DR OpenTargets; ENSG00000205442; -.
DR VEuPathDB; HostDB:ENSG00000205442; -.
DR eggNOG; ENOG502S8ID; Eukaryota.
DR GeneTree; ENSGT00390000017601; -.
DR HOGENOM; CLU_103188_0_0_1; -.
DR InParanoid; Q5VZ72; -.
DR OMA; SEDCIVT; -.
DR OrthoDB; 1563154at2759; -.
DR PhylomeDB; Q5VZ72; -.
DR TreeFam; TF339468; -.
DR PathwayCommons; Q5VZ72; -.
DR Reactome; R-HSA-1300645; Acrosome Reaction and Sperm:Oocyte Membrane Binding.
DR SignaLink; Q5VZ72; -.
DR BioGRID-ORCS; 100129669; 7 hits in 1037 CRISPR screens.
DR Pharos; Q5VZ72; Tdark.
DR PRO; PR:Q5VZ72; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q5VZ72; protein.
DR Bgee; ENSG00000205442; Expressed in left testis and 10 other tissues.
DR ExpressionAtlas; Q5VZ72; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR InterPro; IPR029389; IZUMO.
DR Pfam; PF15005; IZUMO; 1.
PE 3: Inferred from homology;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..239
FT /note="Izumo sperm-egg fusion protein 3"
FT /id="PRO_0000342457"
FT TOPO_DOM 21..174
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 96
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 126
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 239 AA; 27768 MW; BC8CF4D1BDCB051B CRC64;
MGDLWLFLLL PLSAFHGVKG CLECDPKFIE DVGSLLGNLI PSEVPGRTQL LERQIKEMIH
LSFKVSHSDK RLRVLAVQQV VKLRTWLKNE FYKLGNETWK GVFIYQGKLL DVCQNLESKL
KELLKNFSEI ACSEDCIVVE GPILDCWTCL RMTNRCFKGE YCGDEDPRKA ENREIALFLI
LLATAVILGS AVLLFHFCIF HRRKMKAIRR SLKEYVEKKL EELMGKIDEK EEKDFRLRK
