ID   IZUM4_MACFA             Reviewed;         219 AA.
AC   Q4R6V5;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=Izumo sperm-egg fusion protein 4;
DE   Flags: Precursor;
GN   Name=IZUMO4; ORFNames=QtsA-17041;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- MISCELLANEOUS: Izumo is the name of a Japanese shrine to marriage.
CC   -!- SIMILARITY: Belongs to the Izumo family. {ECO:0000305}.
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DR   EMBL; AB169075; BAE01169.1; -; mRNA.
DR   RefSeq; NP_001274619.1; NM_001287690.1.
DR   AlphaFoldDB; Q4R6V5; -.
DR   STRING; 9541.XP_005587503.1; -.
DR   Ensembl; ENSMFAT00000033218; ENSMFAP00000025071; ENSMFAG00000044044.
DR   GeneID; 102139078; -.
DR   CTD; 113177; -.
DR   eggNOG; ENOG502SNMJ; Eukaryota.
DR   GeneTree; ENSGT00390000015418; -.
DR   Proteomes; UP000233100; Chromosome 19.
DR   Bgee; ENSMFAG00000044044; Expressed in pituitary gland and 10 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR029389; IZUMO.
DR   Pfam; PF15005; IZUMO; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..219
FT                   /note="Izumo sperm-egg fusion protein 4"
FT                   /id="PRO_0000278187"
FT   CARBOHYD        206
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   219 AA;  25081 MW;  967E59B5537274D7 CRC64;
     MALLLCLVGV TAALAHGCLH CHSKFSEKFS FYRHHVNLKS WWVGDIPVSG ALLTDWSDDT
     MKELHLAIPA EITREKLDQV ATAVYQRMDQ LYQGKMYFPG YFPNELRNIF REQVHLIQNA
     IIESRLDCQR HCGIFQYETI SCNNCTDSHV ACFGYNCESS EQWESAVQGL LNYINNWHKQ
     DVSMRATPAF LVSPAFRCLE PPHLANLTLE DAAECLKQH