ID   J5_VACCA                Reviewed;         133 AA.
AC   Q76VD9;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Protein J5;
GN   OrderedLocusNames=MVA089L, ACAM3000_MVA_089;
OS   Vaccinia virus (strain Ankara) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=126794;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9601507; DOI=10.1006/viro.1998.9123;
RA   Antoine G., Scheiflinger F., Dorner F., Falkner F.G.;
RT   "The complete genomic sequence of the modified vaccinia Ankara strain:
RT   comparison with other orthopoxviruses.";
RL   Virology 244:365-396(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate Acambis 3000;
RA   Esposito J.J., Frace M., Sammons S.A., Olsen-Rasmussen M.S., Osborne J.,
RA   Khristova M., Wohlhueter R.M.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Envelope protein part of the entry-fusion complex responsible
CC       for the virus membrane fusion with host cell membrane during virus
CC       entry. Also plays a role in cell-cell fusion (syncytium formation) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of a stable entry-fusion complex (EFC) which is at least
CC       composed of proteins A16, A21, A28, G3, G9, H2, J5, and L5. Formation
CC       of the viral membrane is necessary for the assembly of the complex (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}. Note=Component of the mature virion
CC       (MV) membrane. The mature virion is located in the cytoplasm of
CC       infected cells and is probably released by cell lysis (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae A16/G9/J5 family. {ECO:0000305}.
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DR   EMBL; U94848; AAB96445.1; -; Genomic_DNA.
DR   EMBL; AY603355; AAT10487.1; -; Genomic_DNA.
DR   RefSeq; YP_232979.1; NC_006998.1.
DR   SMR; Q76VD9; -.
DR   DNASU; 3707553; -.
DR   GeneID; 3707553; -.
DR   KEGG; vg:3707553; -.
DR   Proteomes; UP000159908; Genome.
DR   Proteomes; UP000172909; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR004251; Pox_virus_G9/A16.
DR   Pfam; PF03003; Pox_G9-A16; 1.
PE   3: Inferred from homology;
KW   Fusion of virus membrane with host cell membrane;
KW   Fusion of virus membrane with host membrane; Membrane; Signal-anchor;
KW   Transmembrane; Transmembrane helix; Viral envelope protein;
KW   Viral penetration into host cytoplasm; Virion; Virus entry into host cell.
FT   CHAIN           1..133
FT                   /note="Protein J5"
FT                   /id="PRO_0000099593"
FT   TOPO_DOM        1..111
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        112..132
FT                   /note="Helical; Signal-anchor"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   133 AA;  15158 MW;  FE7D976F31B87309 CRC64;
     MTDEQIYAFC DANKDDIRCK CIYPDKSIVR IGIDTRLPYY CWYEPCKRSD ALLPASLKKN
     ITKCNVSDCT ISLGNVSITD SKLDVNNVCD SKRVATENIA VRYLNQEIRY PIIDIKWLPI
     GLLALAILIL AFF