ID   J5_VACCW                Reviewed;         133 AA.
AC   P07618;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 2.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Protein J5;
DE   AltName: Full=Protein F11;
GN   OrderedLocusNames=VACWR097; ORFNames=J5L;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2987815; DOI=10.1093/nar/13.3.985;
RA   Plucienniczak A., Schroeder E., Zettlmeissl G., Streeck R.E.;
RT   "Nucleotide sequence of a cluster of early and late genes in a conserved
RT   segment of the vaccinia virus genome.";
RL   Nucleic Acids Res. 13:985-998(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3517852; DOI=10.1073/pnas.83.10.3141;
RA   Broyles S.S., Moss B.;
RT   "Homology between RNA polymerases of poxviruses, prokaryotes, and
RT   eukaryotes: nucleotide sequence and transcriptional analysis of vaccinia
RT   virus genes encoding 147-kDa and 22-kDa subunits.";
RL   Proc. Natl. Acad. Sci. U.S.A. 83:3141-3145(1986).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   IDENTIFICATION IN A COMPLEX WITH A16; A21; A28; G3; G9; H2 AND L5.
RX   PubMed=16339313; DOI=10.1073/pnas.0509239102;
RA   Senkevich T.G., Ojeda S., Townsley A., Nelson G.E., Moss B.;
RT   "Poxvirus multiprotein entry-fusion complex.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:18572-18577(2005).
CC   -!- FUNCTION: Envelope protein part of the entry-fusion complex responsible
CC       for the virus membrane fusion with host cell membrane during virus
CC       entry. Also plays a role in cell-cell fusion (syncytium formation).
CC   -!- SUBUNIT: Part of a stable entry-fusion complex (EFC) which is at least
CC       composed of proteins A16, A21, A28, G3, G9, H2, J5, and L5. Formation
CC       of the viral membrane is necessary for the assembly of the complex.
CC       {ECO:0000269|PubMed:16339313}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}. Note=Component of the mature virion
CC       (MV) membrane. The mature virion is located in the cytoplasm of
CC       infected cells and is probably released by cell lysis.
CC   -!- SIMILARITY: Belongs to the poxviridae A16/G9/J5 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA26019.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; X01978; CAA26019.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; M13209; AAB59834.1; -; Genomic_DNA.
DR   EMBL; AY243312; AAO89376.1; -; Genomic_DNA.
DR   PIR; B26216; QQVZEL.
DR   RefSeq; YP_232979.1; NC_006998.1.
DR   SMR; P07618; -.
DR   IntAct; P07618; 1.
DR   MINT; P07618; -.
DR   DNASU; 3707553; -.
DR   GeneID; 3707553; -.
DR   KEGG; vg:3707553; -.
DR   Proteomes; UP000000344; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR004251; Pox_virus_G9/A16.
DR   Pfam; PF03003; Pox_G9-A16; 1.
PE   1: Evidence at protein level;
KW   Fusion of virus membrane with host cell membrane;
KW   Fusion of virus membrane with host membrane; Membrane; Reference proteome;
KW   Signal-anchor; Transmembrane; Transmembrane helix; Viral envelope protein;
KW   Viral penetration into host cytoplasm; Virion; Virus entry into host cell.
FT   CHAIN           1..133
FT                   /note="Protein J5"
FT                   /id="PRO_0000099595"
FT   TOPO_DOM        1..111
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        112..132
FT                   /note="Helical; Signal-anchor"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   133 AA;  15158 MW;  FE7D976F31B87309 CRC64;
     MTDEQIYAFC DANKDDIRCK CIYPDKSIVR IGIDTRLPYY CWYEPCKRSD ALLPASLKKN
     ITKCNVSDCT ISLGNVSITD SKLDVNNVCD SKRVATENIA VRYLNQEIRY PIIDIKWLPI
     GLLALAILIL AFF