ID   JADE3_DANRE             Reviewed;         795 AA.
AC   Q7ZVP1;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Protein Jade-3;
DE   AltName: Full=Jade family PHD finger protein 3;
DE   AltName: Full=PHD finger protein 16;
GN   Name=jade3; Synonyms=phf16;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=14612400; DOI=10.1128/mcb.23.23.8553-8562.2003;
RA   Tzouanacou E., Tweedie S., Wilson V.;
RT   "Identification of Jade1, a gene encoding a PHD zinc finger protein, in a
RT   gene trap mutagenesis screen for genes involved in anteroposterior axis
RT   development.";
RL   Mol. Cell. Biol. 23:8553-8562(2003).
CC   -!- FUNCTION: Scaffold subunit of some HBO1 complexes, which have a histone
CC       H4 acetyltransferase activity. {ECO:0000250|UniProtKB:Q92613}.
CC   -!- SUBUNIT: Component of the HBO1 complex. {ECO:0000250|UniProtKB:Q92613}.
CC   -!- SIMILARITY: Belongs to the JADE family. {ECO:0000305}.
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DR   EMBL; BC045468; AAH45468.1; -; mRNA.
DR   EMBL; BN000277; CAE30492.1; -; mRNA.
DR   AlphaFoldDB; Q7ZVP1; -.
DR   SMR; Q7ZVP1; -.
DR   STRING; 7955.ENSDARP00000120486; -.
DR   PaxDb; Q7ZVP1; -.
DR   PRIDE; Q7ZVP1; -.
DR   ZFIN; ZDB-GENE-030131-928; jade3.
DR   eggNOG; KOG0954; Eukaryota.
DR   InParanoid; Q7ZVP1; -.
DR   PhylomeDB; Q7ZVP1; -.
DR   Reactome; R-DRE-3214847; HATs acetylate histones.
DR   PRO; PR:Q7ZVP1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0000123; C:histone acetyltransferase complex; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd15681; PHD_JADE3; 1.
DR   Gene3D; 3.30.40.10; -; 2.
DR   InterPro; IPR019542; Enhancer_polycomb-like_N.
DR   InterPro; IPR034732; EPHD.
DR   InterPro; IPR039550; JADE3_PHD.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF10513; EPL1; 1.
DR   SMART; SM00249; PHD; 2.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS51805; EPHD; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..795
FT                   /note="Protein Jade-3"
FT                   /id="PRO_0000253535"
FT   ZN_FING         201..251
FT                   /note="PHD-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT   ZN_FING         253..287
FT                   /note="C2HC pre-PHD-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01146"
FT   ZN_FING         311..367
FT                   /note="PHD-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01146"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          630..654
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          667..687
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          714..795
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..32
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        720..737
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   795 AA;  89044 MW;  513B5703FFC59F6C CRC64;
     MKRLRTPSSS DSSDNESPST SFSSNKYGSK PGTPASAQKK PAEVFRKDLI SAMKLPDSHH
     ISSEDYYLLA DTWKQEWEKG VQVLASPDTI PQPSVRIITE KPKEVLFSKP RKYIQCWSQD
     STETGYVNIK ELAEAMCRYD LDDMDLYWLQ QLNAELGMMG DGVVDELTME RVMEALERQC
     HENMNHAIET EEGLGIEYDE DVICDVCRSP DSEEGNDMVF CDKCNICVHQ ACYGIVKVPD
     GNWLCRTCVL GITPQCLLCP KTGGAMKATR AGTKWAHVSC ALWIPEVSIA CPERMEPITK
     VSHIPPSRWS LICSLCKLKT GACIQCSVKN CTIPFHVTCA FEHSLEMKTI LDEGDEVKFK
     SYCLKHSKPK AGEPGLSPAR HKPPTETDKL SLRAQKLQEL EEEFYTYVHP EEVAHDLSLP
     LHLLDFIFQY WKMKRKSNFN KALLPPKEDE ENLLLQPQED SIHTRMRMFM HLRQDLERVR
     NLCYMVSRRE KLKLSQSKAQ EQIFNLHVKL VNQELSAGLP VSSSIENLLF HPPPRITLKL
     KMPKVQLGNG KSSSKSGNGP LCPDNSCNLY DTSEGGIGQG KPQLHLGRQR IEERINGILP
     ASIYIRRDGG TPPLAVKQSG KPLALHAALH GQSSNGKTKN EAEKSRQIKS NGILDKPILQ
     RDTSCLAASE KDPRSEISGK SQSSGFHKTS LEHFSRSLKE ATVSLVRTED LRTFEKNSRK
     SSGFSKPLST ERPQGGGRAS QESDGYCPDA ELSDSEPEAK GKCRQGGRTQ NQRGDYVKSA
     SRAKHSYGSR TSVQR