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JADE3_XENTR
ID   JADE3_XENTR             Reviewed;         817 AA.
AC   Q0P4S5;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Protein Jade-3;
DE   AltName: Full=Jade family PHD finger protein 3;
DE   AltName: Full=PHD finger protein 16;
GN   Name=jade3; Synonyms=phf16;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Scaffold subunit of some HBO1 complexes, which have a histone
CC       H4 acetyltransferase activity. {ECO:0000250|UniProtKB:Q92613}.
CC   -!- SUBUNIT: Component of the HBO1 complex. {ECO:0000250|UniProtKB:Q92613}.
CC   -!- SIMILARITY: Belongs to the JADE family. {ECO:0000305}.
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DR   EMBL; BC121924; AAI21925.1; -; mRNA.
DR   RefSeq; NP_001072493.1; NM_001079025.1.
DR   RefSeq; XP_017946833.1; XM_018091344.1.
DR   AlphaFoldDB; Q0P4S5; -.
DR   SMR; Q0P4S5; -.
DR   STRING; 8364.ENSXETP00000022862; -.
DR   PaxDb; Q0P4S5; -.
DR   GeneID; 779948; -.
DR   KEGG; xtr:779948; -.
DR   CTD; 9767; -.
DR   Xenbase; XB-GENE-978173; jade3.
DR   eggNOG; KOG0954; Eukaryota.
DR   HOGENOM; CLU_016215_1_0_1; -.
DR   InParanoid; Q0P4S5; -.
DR   OMA; EFHRGQP; -.
DR   OrthoDB; 1235709at2759; -.
DR   TreeFam; TF316118; -.
DR   Reactome; R-XTR-3214847; HATs acetylate histones.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0000123; C:histone acetyltransferase complex; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd15681; PHD_JADE3; 1.
DR   Gene3D; 3.30.40.10; -; 2.
DR   InterPro; IPR019542; Enhancer_polycomb-like_N.
DR   InterPro; IPR034732; EPHD.
DR   InterPro; IPR039550; JADE3_PHD.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF10513; EPL1; 1.
DR   SMART; SM00249; PHD; 2.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS51805; EPHD; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..817
FT                   /note="Protein Jade-3"
FT                   /id="PRO_0000253536"
FT   ZN_FING         202..252
FT                   /note="PHD-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT   ZN_FING         254..288
FT                   /note="C2HC pre-PHD-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01146"
FT   ZN_FING         312..368
FT                   /note="PHD-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01146"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          375..396
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          665..689
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          719..817
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        667..689
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        724..742
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        743..759
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        775..800
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   817 AA;  92589 MW;  C424B0AFC2E4A78D CRC64;
     MKRLRNLSSS DSSDNESPST SFSSCFQHKG KGKCTADDGK KSAEVFRKDL ISAMKIPDSQ
     HVNPEEYYQF ADTWKQEWEK GVQVPSNPEN IPQPSLRVIA EKAKEVLFTR PRKYIHCSSQ
     EPAEPGYINI LELAESMCRY DLDDLDLYWL GECNLELADM GCAPVDESTM EKTLEVLERQ
     CHENMNHAIE TEEGLGIEYD EDVICDVCRS PDSEEGNDMV FCDRCNICVH QACYGILKVP
     EGSWLCRTCV LGLHPQCILC PKTGGAMKAT RTGTKWAHVS CALWIPEVSI ACPERMEPIT
     KVSHIPPSRW ALVCSLCKLK TGACIQCSVK SCITAFHVTC AFEHSLEMKT ILDEGDEVKF
     KSYCLKHSKN KHGLISEQEE PHKTHSDNRP TESERTSLRA QKLKELEEDF YTLVKVEDVA
     AELGLPMLTV DFIYSFWKLK RKSNFNKPLL TPKEDEQNGL VQPKEDSIHT RMRMFMHLRQ
     DLERVRNLCY MVNRREKLKL SHSKMHEEIF NLQVQLVNQE VAAGQPLSNA LENTLFYPPP
     RITLKLKMPK PRTRDCRISS VKAGTMSSPD NQNSSATYHG MGGEVHRQSS EHTKLYSTYA
     SEQRNNGLLG GITRFHKEFQ GTGCKPSSRF RSSGKPMSLQ AVIHGQSSNG SGKVQHEHVS
     LARANGVLSS GDRTQRDSSS QTSPGQNSEI ICHIAGQSTF RKANMEHFSR SFKEATNNLV
     RTTEDLRSSE KPQRRQSVKE RLWSKQPADT QTSGTPYQDN DGYCPDLELS DSEAESDENK
     DHMLLRRNSR ESPNRDSCRN SRIRGKRKMT SHSSVQR
 
 
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