ID   JAGN1_BOVIN             Reviewed;         183 AA.
AC   Q2NKY9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Protein jagunal homolog 1 {ECO:0000305};
GN   Name=JAGN1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Endoplasmic reticulum transmembrane protein involved in
CC       vesicle-mediated transport, which is required for neutrophil function.
CC       Required for vesicle-mediated transport; it is however unclear whether
CC       it is involved in early secretory pathway or intracellular protein
CC       transport. Acts as a regulator of neutrophil function, probably via its
CC       role in vesicle-mediated transport: required for defense against fungal
CC       pathogens and for granulocyte colony-stimulating factor (GM-CSF)
CC       signaling pathway; possibly by regulating glycosylation and/or
CC       targeting of proteins contributing to the viability and migration of
CC       neutrophils. {ECO:0000250|UniProtKB:Q5XKN4,
CC       ECO:0000250|UniProtKB:Q8N5M9}.
CC   -!- SUBUNIT: Interacts with COPA, COPB2 and COPG2.
CC       {ECO:0000250|UniProtKB:Q8N5M9}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q8N5M9}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the jagunal family. {ECO:0000305}.
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DR   EMBL; BC111343; AAI11344.1; -; mRNA.
DR   RefSeq; NP_001039915.1; NM_001046450.2.
DR   AlphaFoldDB; Q2NKY9; -.
DR   SMR; Q2NKY9; -.
DR   STRING; 9913.ENSBTAP00000030786; -.
DR   PaxDb; Q2NKY9; -.
DR   PRIDE; Q2NKY9; -.
DR   Ensembl; ENSBTAT00000030816; ENSBTAP00000030786; ENSBTAG00000010832.
DR   GeneID; 539101; -.
DR   KEGG; bta:539101; -.
DR   CTD; 84522; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010832; -.
DR   VGNC; VGNC:30363; JAGN1.
DR   eggNOG; KOG4054; Eukaryota.
DR   GeneTree; ENSGT00390000005596; -.
DR   HOGENOM; CLU_121621_0_0_1; -.
DR   InParanoid; Q2NKY9; -.
DR   OMA; VWRGYPY; -.
DR   OrthoDB; 1452436at2759; -.
DR   TreeFam; TF313137; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000010832; Expressed in oocyte and 106 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; ISS:UniProtKB.
DR   GO; GO:0007029; P:endoplasmic reticulum organization; IBA:GO_Central.
DR   GO; GO:0038158; P:granulocyte colony-stimulating factor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0030223; P:neutrophil differentiation; ISS:UniProtKB.
DR   GO; GO:0002446; P:neutrophil mediated immunity; ISS:UniProtKB.
DR   GO; GO:1990266; P:neutrophil migration; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB.
DR   InterPro; IPR009787; Jagunal.
DR   PANTHER; PTHR20955; PTHR20955; 1.
DR   Pfam; PF07086; Jagunal; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Immunity; Membrane; Phosphoprotein;
KW   Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..183
FT                   /note="Protein jagunal homolog 1"
FT                   /id="PRO_0000313607"
FT   TOPO_DOM        1..39
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        61..71
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        93..96
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        118..137
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..183
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         3
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N5M9"
SQ   SEQUENCE   183 AA;  21102 MW;  C458707A7270B30B CRC64;
     MASRAGPRAA GTDGSDFQHR ERVAMHYQMS VTLKYEIKKL IYVHLVIWLL LVAKMSVGHL
     RLLSHDQVAM PYQWEYPYLL SVVPSLLGLL SFPRNNISYL VLSMISMGLF SIAPLIYGSM
     EMFPAAQQLY RHGKAYRFLF GFSAVSVMYL VLVLAVQVHA WQLYYSKKLL DSWFTSTQEK
     KRK