ID   JAGN1_XENLA             Reviewed;         183 AA.
AC   Q5M7C7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Protein jagunal homolog 1 {ECO:0000305};
GN   Name=jagn1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Endoplasmic reticulum transmembrane protein involved in
CC       vesicle-mediated transport, which is required for neutrophil function.
CC       {ECO:0000250|UniProtKB:Q5XKN4, ECO:0000250|UniProtKB:Q8N5M9}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q8N5M9}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the jagunal family. {ECO:0000305}.
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DR   EMBL; BC088709; AAH88709.1; -; mRNA.
DR   RefSeq; NP_001088895.1; NM_001095426.1.
DR   RefSeq; XP_018112385.1; XM_018256896.1.
DR   AlphaFoldDB; Q5M7C7; -.
DR   SMR; Q5M7C7; -.
DR   DNASU; 496241; -.
DR   GeneID; 496241; -.
DR   KEGG; xla:496241; -.
DR   CTD; 496241; -.
DR   Xenbase; XB-GENE-5948919; jagn1.L.
DR   OMA; IWILMAA; -.
DR   OrthoDB; 1452436at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 496241; Expressed in testis and 19 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; ISS:UniProtKB.
DR   GO; GO:0007029; P:endoplasmic reticulum organization; IEA:InterPro.
DR   GO; GO:0038158; P:granulocyte colony-stimulating factor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0030223; P:neutrophil differentiation; ISS:UniProtKB.
DR   GO; GO:0002446; P:neutrophil mediated immunity; ISS:UniProtKB.
DR   GO; GO:1990266; P:neutrophil migration; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB.
DR   InterPro; IPR009787; Jagunal.
DR   PANTHER; PTHR20955; PTHR20955; 1.
DR   Pfam; PF07086; Jagunal; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Immunity; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..183
FT                   /note="Protein jagunal homolog 1"
FT                   /id="PRO_0000313613"
FT   TOPO_DOM        1..39
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        61..71
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        93..99
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..137
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..183
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   183 AA;  20978 MW;  DB12244BCEB7AED1 CRC64;
     MASRAGPRAT GSDGSDFQHR EKVAGHYKMS ASLKNEIKKL IYAHLIIWML IAAQMCVSHL
     KLVSKDLVAM PYQWEYPYLL SLVPSLFGLF SFPRNNISYL VISMISTGLF SIGPLIYGTL
     EMFPMAQQLY RHGKAYRFIF GFSAISVMYL VMVVAVQVHG WQIYYSKKLL DSWFTNTQEK
     KKK