ID   JAGN1_XENTR             Reviewed;         183 AA.
AC   Q6NVQ1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Protein jagunal homolog 1 {ECO:0000305};
GN   Name=jagn1; ORFNames=TNeu044c16.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Endoplasmic reticulum transmembrane protein involved in
CC       vesicle-mediated transport, which is required for neutrophil function.
CC       {ECO:0000250|UniProtKB:Q5XKN4, ECO:0000250|UniProtKB:Q8N5M9}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q8N5M9}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the jagunal family. {ECO:0000305}.
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DR   EMBL; CR760294; CAJ83110.1; -; mRNA.
DR   EMBL; BC067954; AAH67954.1; -; mRNA.
DR   RefSeq; NP_001001898.1; NM_001001898.1.
DR   RefSeq; XP_017948473.1; XM_018092984.1.
DR   RefSeq; XP_017948474.1; XM_018092985.1.
DR   AlphaFoldDB; Q6NVQ1; -.
DR   SMR; Q6NVQ1; -.
DR   DNASU; 431675; -.
DR   Ensembl; ENSXETT00000095536; ENSXETP00000073722; ENSXETG00000038177.
DR   GeneID; 431675; -.
DR   KEGG; xtr:431675; -.
DR   CTD; 84522; -.
DR   Xenbase; XB-GENE-5948803; jagn1.
DR   InParanoid; Q6NVQ1; -.
DR   OrthoDB; 1452436at2759; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000038177; Expressed in neurula embryo and 12 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; ISS:UniProtKB.
DR   GO; GO:0007029; P:endoplasmic reticulum organization; IBA:GO_Central.
DR   GO; GO:0038158; P:granulocyte colony-stimulating factor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0030223; P:neutrophil differentiation; ISS:UniProtKB.
DR   GO; GO:0002446; P:neutrophil mediated immunity; ISS:UniProtKB.
DR   GO; GO:1990266; P:neutrophil migration; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB.
DR   InterPro; IPR009787; Jagunal.
DR   PANTHER; PTHR20955; PTHR20955; 1.
DR   Pfam; PF07086; Jagunal; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Immunity; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..183
FT                   /note="Protein jagunal homolog 1"
FT                   /id="PRO_0000313614"
FT   TOPO_DOM        1..39
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        61..71
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        93..99
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..137
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..183
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   183 AA;  20982 MW;  2F366D8928FDDA33 CRC64;
     MASRAGPRAT GTDGSDFQHR ERVASHYQMS ASLKNEIKKL IYAHLVIWLL IAAQMCVSHL
     KLVSKDLVAM PYQWEYPYLL SLVPSLFGLV SFPRNNISYL VISMISTGLF SIAPLIYGTL
     EMFPMAQQLY RHGKAYRFIF GFSAISVMYL LMVVAVQVHG WQIYYSKKLL DAWFTNTQEK
     KKK