JAGN_DROME
ID JAGN_DROME Reviewed; 197 AA.
AC Q7K1V5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Protein jagunal {ECO:0000303|PubMed:17389229};
GN Name=jagn {ECO:0000303|PubMed:17389229, ECO:0000312|FlyBase:FBgn0037374};
GN ORFNames=CG10978;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP FUNCTION, MUTAGENESIS OF ASP-16, SUBCELLULAR LOCATION, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=17389229; DOI=10.1083/jcb.200701048;
RA Lee S., Cooley L.;
RT "Jagunal is required for reorganizing the endoplasmic reticulum during
RT Drosophila oogenesis.";
RL J. Cell Biol. 176:941-952(2007).
CC -!- FUNCTION: Required for endoplasmic reticulum organization and proper
CC vesicular traffic during vitellogenesis. Required for oocyte and
CC bristle growth. {ECO:0000269|PubMed:17389229}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:17389229}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:17389229}.
CC -!- DISRUPTION PHENOTYPE: Mutants can't increase the size of their oocyte
CC during oogenesis. {ECO:0000269|PubMed:17389229}.
CC -!- MISCELLANEOUS: 'Jagunal' means 'small egg'.
CC {ECO:0000305|PubMed:17389229}.
CC -!- SIMILARITY: Belongs to the jagunal family. {ECO:0000305}.
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DR EMBL; AE014297; AAN14321.1; -; Genomic_DNA.
DR EMBL; AY061443; AAL28991.1; -; mRNA.
DR RefSeq; NP_649585.1; NM_141328.3.
DR RefSeq; NP_731002.1; NM_169103.2.
DR AlphaFoldDB; Q7K1V5; -.
DR SMR; Q7K1V5; -.
DR BioGRID; 65919; 32.
DR IntAct; Q7K1V5; 5.
DR STRING; 7227.FBpp0078273; -.
DR PaxDb; Q7K1V5; -.
DR PRIDE; Q7K1V5; -.
DR DNASU; 40714; -.
DR EnsemblMetazoa; FBtr0078624; FBpp0078273; FBgn0037374.
DR EnsemblMetazoa; FBtr0078625; FBpp0078274; FBgn0037374.
DR GeneID; 40714; -.
DR KEGG; dme:Dmel_CG10978; -.
DR UCSC; CG10978-RA; d. melanogaster.
DR CTD; 40714; -.
DR FlyBase; FBgn0037374; jagn.
DR VEuPathDB; VectorBase:FBgn0037374; -.
DR eggNOG; KOG4054; Eukaryota.
DR GeneTree; ENSGT00390000005596; -.
DR HOGENOM; CLU_121621_0_0_1; -.
DR InParanoid; Q7K1V5; -.
DR OMA; VWRGYPY; -.
DR OrthoDB; 1452436at2759; -.
DR PhylomeDB; Q7K1V5; -.
DR BioGRID-ORCS; 40714; 0 hits in 1 CRISPR screen.
DR ChiTaRS; jagn; fly.
DR GenomeRNAi; 40714; -.
DR PRO; PR:Q7K1V5; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0037374; Expressed in embryonic/larval hemocyte (Drosophila) and 35 other tissues.
DR ExpressionAtlas; Q7K1V5; baseline and differential.
DR Genevisible; Q7K1V5; DM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022416; P:chaeta development; IMP:UniProtKB.
DR GO; GO:0008407; P:chaeta morphogenesis; IMP:FlyBase.
DR GO; GO:0007029; P:endoplasmic reticulum organization; IMP:UniProtKB.
DR GO; GO:0051686; P:establishment of ER localization; IMP:FlyBase.
DR GO; GO:0006887; P:exocytosis; IMP:UniProtKB.
DR GO; GO:0001555; P:oocyte growth; IMP:UniProtKB.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0007296; P:vitellogenesis; IMP:FlyBase.
DR InterPro; IPR009787; Jagunal.
DR PANTHER; PTHR20955; PTHR20955; 1.
DR Pfam; PF07086; Jagunal; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; Endoplasmic reticulum; Membrane;
KW Oogenesis; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..197
FT /note="Protein jagunal"
FT /id="PRO_0000313615"
FT TOPO_DOM 1..39
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..78
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..109
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..159
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..197
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MUTAGEN 16
FT /note="D->N: Semi-lethal."
FT /evidence="ECO:0000269|PubMed:17389229"
SQ SEQUENCE 197 AA; 23036 MW; 0B4DF7CF8DA49B6C CRC64;
MATRGGPMVA GTDGNDFEFR QRVAGTYQIS LLNKSRLKYC IFFHALLFFV MLAKLTSDIL
DHLDIFVLEI EELEVPPPLW WEYVWAASLL TSFLGLSAAR GNKVREMQKY MVAILLFAIL
PLFYCFAYYF SDVWEFATLD KSVELDETDI FVWRGYPYGV FWYAFCFVGF QVHGFTLYFA
YNLVKAWKAR TATRKFQ
