JAGN_DROPS
ID JAGN_DROPS Reviewed; 197 AA.
AC Q297K8;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Protein jagunal {ECO:0000250|UniProtKB:Q7K1V5};
GN Name=jagn {ECO:0000250|UniProtKB:Q7K1V5}; ORFNames=GA10683;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Required for endoplasmic reticulum organization and proper
CC vesicular traffic during vitellogenesis. Required for oocyte and
CC bristle growth. {ECO:0000250|UniProtKB:Q7K1V5}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q7K1V5}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q7K1V5}.
CC -!- SIMILARITY: Belongs to the jagunal family. {ECO:0000305}.
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DR EMBL; CM000070; EAL28197.1; -; Genomic_DNA.
DR RefSeq; XP_001359054.1; XM_001359017.3.
DR AlphaFoldDB; Q297K8; -.
DR SMR; Q297K8; -.
DR STRING; 7237.FBpp0284177; -.
DR EnsemblMetazoa; FBtr0285739; FBpp0284177; FBgn0070739.
DR GeneID; 4802061; -.
DR KEGG; dpo:Dpse_GA10683; -.
DR eggNOG; KOG4054; Eukaryota.
DR HOGENOM; CLU_121621_0_0_1; -.
DR InParanoid; Q297K8; -.
DR OMA; VWRGYPY; -.
DR PhylomeDB; Q297K8; -.
DR ChiTaRS; jagn; fly.
DR Proteomes; UP000001819; Chromosome 2.
DR Bgee; FBgn0070739; Expressed in female reproductive system and 2 other tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022416; P:chaeta development; ISS:UniProtKB.
DR GO; GO:0008407; P:chaeta morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0007029; P:endoplasmic reticulum organization; ISS:UniProtKB.
DR GO; GO:0051686; P:establishment of ER localization; IEA:EnsemblMetazoa.
DR GO; GO:0006887; P:exocytosis; ISS:UniProtKB.
DR GO; GO:0001555; P:oocyte growth; ISS:UniProtKB.
DR GO; GO:0007296; P:vitellogenesis; IEA:EnsemblMetazoa.
DR InterPro; IPR009787; Jagunal.
DR PANTHER; PTHR20955; PTHR20955; 1.
DR Pfam; PF07086; Jagunal; 1.
PE 3: Inferred from homology;
KW Developmental protein; Differentiation; Endoplasmic reticulum; Membrane;
KW Oogenesis; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..197
FT /note="Protein jagunal"
FT /id="PRO_0000313616"
FT TOPO_DOM 1..39
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..78
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..109
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..159
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..197
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 197 AA; 23057 MW; 2F78004E663D0E59 CRC64;
MATRGGPMVA GTDGNDFEFR QRVAGTYQIS LLNKSRLKYC IFFHALLFFV MLAKLTSDIL
DRLDIFVLEI EELEVPSPLW WEYVWAGSLL TSFLGLSAAR GNKVREMQKY MIAILVFAIL
PLLYCFAYYF SDVWEFATMD KSVELDETDI FIWRGYPYGV FWYAFCFVGF QVHGFTLYFA
YNLVKVWKAR TATRKFQ
