JAG_ARATH
ID JAG_ARATH Reviewed; 253 AA.
AC Q6S591; Q9CA33;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Zinc finger protein JAGGED;
GN Name=JAG; OrderedLocusNames=At1g68480; ORFNames=T26J14.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=14973282; DOI=10.1242/dev.00949;
RA Dinneny J.R., Yadegari R., Fischer R.L., Yanofsky M.F., Weigel D.;
RT "The role of JAGGED in shaping lateral organs.";
RL Development 131:1101-1110(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=14973281; DOI=10.1242/dev.00991;
RA Ohno C.K., Reddy G.V., Heisler M.G., Meyerowitz E.M.;
RT "The Arabidopsis JAGGED gene encodes a zinc finger protein that promotes
RT leaf tissue development.";
RL Development 131:1111-1122(2004).
RN [5]
RP FUNCTION.
RX PubMed=16192305; DOI=10.1242/dev.02062;
RA Dinneny J.R., Weigel D., Yanofsky M.F.;
RT "A genetic framework for fruit patterning in Arabidopsis thaliana.";
RL Development 132:4687-4696(2005).
RN [6]
RP FUNCTION.
RX PubMed=16554365; DOI=10.1242/dev.02335;
RA Dinneny J.R., Weigel D., Yanofsky M.F.;
RT "NUBBIN and JAGGED define stamen and carpel shape in Arabidopsis.";
RL Development 133:1645-1655(2006).
RN [7]
RP FUNCTION.
RX PubMed=18156293; DOI=10.1104/pp.107.113787;
RA Xu B., Li Z., Zhu Y., Wang H., Ma H., Dong A., Huang H.;
RT "Arabidopsis genes AS1, AS2, and JAG negatively regulate boundary-
RT specifying genes to promote sepal and petal development.";
RL Plant Physiol. 146:566-575(2008).
RN [8]
RP INTERACTION WITH GATA18/HAN, DISRUPTION PHENOTYPE, INDUCTION BY GATA18/HAN,
RP AND TISSUE SPECIFICITY.
RX PubMed=26390296; DOI=10.1371/journal.pgen.1005479;
RA Ding L., Yan S., Jiang L., Zhao W., Ning K., Zhao J., Liu X., Zhang J.,
RA Wang Q., Zhang X.;
RT "HANABA TARANU (HAN) bridges meristem and organ primordia boundaries
RT through PINHEAD, JAGGED, BLADE-ON-PETIOLE2 and CYTOKININ OXIDASE 3 during
RT flower development in Arabidopsis.";
RL PLoS Genet. 11:E1005479-E1005479(2015).
CC -!- FUNCTION: Controls the morphogenesis of lateral organs. Functions in
CC lateral organ shape and is sufficient to induce proliferation and
CC growth of lateral organ tissue. Is necessary and sufficient for bract
CC formation, but its expression is excluded from the cryptic bract, which
CC could be a cause of bractless flowers in Arabidopsis. Participates with
CC FIL and YAB3 in regulating valve margin development. Functions with JGL
CC to define stamen and carpel shape. Functions with AS1 and AS2 in the
CC sepal and petal primordia to repress boundary-specifying genes for
CC normal development of the organs. {ECO:0000269|PubMed:14973281,
CC ECO:0000269|PubMed:14973282, ECO:0000269|PubMed:16192305,
CC ECO:0000269|PubMed:16554365, ECO:0000269|PubMed:18156293}.
CC -!- SUBUNIT: Interacts with GATA18/HAN. {ECO:0000269|PubMed:26390296}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14973281,
CC ECO:0000269|PubMed:14973282}.
CC -!- TISSUE SPECIFICITY: Expressed in the emerging leaf, sepal, petal,
CC stamen and carpel primordia (PubMed:26390296). Not expressed in the
CC apical shoot meristem (SAM). {ECO:0000269|PubMed:14973281,
CC ECO:0000269|PubMed:14973282, ECO:0000269|PubMed:26390296}.
CC -!- INDUCTION: Stimulated by GATA18/HAN. {ECO:0000269|PubMed:26390296}.
CC -!- DISRUPTION PHENOTYPE: Lateral organs with serrated margins. Irregular
CC shape of floral organs. The double mutant han-2 jag-3 exhibits reduced
CC petal numbers, more serrated sepals and narrower petals
CC (PubMed:26390296). {ECO:0000269|PubMed:14973281,
CC ECO:0000269|PubMed:14973282, ECO:0000269|PubMed:26390296}.
CC -!- MISCELLANEOUS: Plants overexpressing JAG form bract-like organs on the
CC inflorescence.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG52397.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY465924; AAR30036.1; -; mRNA.
DR EMBL; AC011915; AAG52397.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE34798.1; -; Genomic_DNA.
DR PIR; H96708; H96708.
DR RefSeq; NP_177015.3; NM_105519.4.
DR AlphaFoldDB; Q6S591; -.
DR SMR; Q6S591; -.
DR BioGRID; 28398; 5.
DR IntAct; Q6S591; 4.
DR STRING; 3702.AT1G68480.1; -.
DR PaxDb; Q6S591; -.
DR PRIDE; Q6S591; -.
DR ProteomicsDB; 232253; -.
DR EnsemblPlants; AT1G68480.1; AT1G68480.1; AT1G68480.
DR GeneID; 843177; -.
DR Gramene; AT1G68480.1; AT1G68480.1; AT1G68480.
DR KEGG; ath:AT1G68480; -.
DR Araport; AT1G68480; -.
DR TAIR; locus:2201302; AT1G68480.
DR eggNOG; ENOG502QUI4; Eukaryota.
DR HOGENOM; CLU_062933_0_0_1; -.
DR InParanoid; Q6S591; -.
DR OMA; YNNINDY; -.
DR OrthoDB; 1361439at2759; -.
DR PhylomeDB; Q6S591; -.
DR PRO; PR:Q6S591; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q6S591; baseline and differential.
DR Genevisible; Q6S591; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0010158; P:abaxial cell fate specification; IMP:TAIR.
DR GO; GO:0048653; P:anther development; IGI:TAIR.
DR GO; GO:0048440; P:carpel development; IGI:TAIR.
DR GO; GO:0009908; P:flower development; IMP:TAIR.
DR GO; GO:0009965; P:leaf morphogenesis; IMP:TAIR.
DR GO; GO:0009909; P:regulation of flower development; IMP:UniProtKB.
DR GO; GO:0010093; P:specification of floral organ identity; IMP:TAIR.
DR GO; GO:0048443; P:stamen development; IGI:TAIR.
DR InterPro; IPR031113; JAGGED-like.
DR InterPro; IPR045320; JAGGED/KNUCKLES-like.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45730; PTHR45730; 1.
DR PANTHER; PTHR45730:SF32; PTHR45730:SF32; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; Metal-binding; Nucleus;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..253
FT /note="Zinc finger protein JAGGED"
FT /id="PRO_0000407988"
FT ZN_FING 51..73
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 253 AA; 28379 MW; 635F638ACC0CA7FA CRC64;
MRHEENYLDL NNLPDDFSKD GNKQALEEGS SSGQRKKKGS KEGKDESGKV YECRFCSLKF
CKSQALGGHM NRHRQERETE TLNQARQLVY RNDTITPPGI SPFGYHHTTD PTIYRSVYSS
PMIYPGSSST NLVPQPPMPP PPPPYPYSSN QYSPHNHFND YYLNPSFRGS RSISPSPNLP
TTTTVDYMAD SPVEPGYTCV GAPIGPTGFP IRGPSIVRAP LEPPQGRDGD ASRQRLDHSL
RFPINRFQDH HSL
