位置:首页 > 蛋白库 > JAL28_ARATH
JAL28_ARATH
ID   JAL28_ARATH             Reviewed;         470 AA.
AC   Q9SDM9; B9DHB6; O04317; Q0WNW3; Q8LB83;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 2.
DT   25-MAY-2022, entry version 124.
DE   RecName: Full=Nitrile-specifier protein 1;
DE            Short=AtNSP1;
DE   AltName: Full=Jacalin-related lectin 28;
GN   Name=NSP1; Synonyms=JAL28; OrderedLocusNames=At3g16400;
GN   ORFNames=MDC8.2, T02O04.11;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Columbia;
RA   Nziengui-Ikapi H., da Silva Conceicao A., Marty F.;
RT   "Arabidopsis thaliana MBP-like genes.";
RL   Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA   Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT   features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT   clones.";
RL   DNA Res. 7:217-221(2000).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA   Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA   Shinozaki K.;
RT   "Analysis of multiple occurrences of alternative splicing events in
RT   Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL   DNA Res. 16:155-164(2009).
RN   [9]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18467340; DOI=10.1093/pcp/pcn075;
RA   Nagano A.J., Fukao Y., Fujiwara M., Nishimura M., Hara-Nishimura I.;
RT   "Antagonistic jacalin-related lectins regulate the size of ER body-type
RT   beta-glucosidase complexes in Arabidopsis thaliana.";
RL   Plant Cell Physiol. 49:969-980(2008).
RN   [10]
RP   FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=18987211; DOI=10.1104/pp.108.130732;
RA   Burow M., Losansky A., Muller R., Plock A., Kliebenstein D.J.,
RA   Wittstock U.;
RT   "The genetic basis of constitutive and herbivore-induced ESP-independent
RT   nitrile formation in Arabidopsis.";
RL   Plant Physiol. 149:561-574(2009).
CC   -!- FUNCTION: Responsible for constitutive and herbivore-induced simple
CC       nitrile formation. Promotes simple nitriles, but not epithionitrile or
CC       thiocyanate formation. Converts allylglucosinolate, 4-
CC       methylsulfinylbutylglucosinolate, 4-methylthiobutylglucosinolate and
CC       benzylglucosinolate to their corresponding simple nitriles in the
CC       presence of myrosinase. {ECO:0000269|PubMed:18987211}.
CC   -!- INDUCTION: By herbivory. {ECO:0000269|PubMed:18987211}.
CC   -!- DISRUPTION PHENOTYPE: No simple nitriles produced.
CC       {ECO:0000269|PubMed:18987211}.
CC   -!- MISCELLANEOUS: Not dependent on the presence of Fe(2+) or Fe(3+).
CC   -!- SIMILARITY: Belongs to the jacalin lectin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01088, ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF214574; AAF25385.1; -; mRNA.
DR   EMBL; AC001645; AAB63638.1; -; Genomic_DNA.
DR   EMBL; AP000373; BAB01138.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE75807.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE75808.1; -; Genomic_DNA.
DR   EMBL; AF375399; AAK52983.1; -; mRNA.
DR   EMBL; AY035036; AAK59541.1; -; mRNA.
DR   EMBL; AY113857; AAM44905.1; -; mRNA.
DR   EMBL; AY125507; AAM78099.1; -; mRNA.
DR   EMBL; AY129466; AAM91052.1; -; mRNA.
DR   EMBL; BT000689; AAN31834.1; -; mRNA.
DR   EMBL; BT000690; AAN31835.1; -; mRNA.
DR   EMBL; AY087364; AAM64914.1; -; mRNA.
DR   EMBL; AK229323; BAF01186.1; -; mRNA.
DR   EMBL; AK317467; BAH20133.1; -; mRNA.
DR   RefSeq; NP_001030709.1; NM_001035632.1.
DR   RefSeq; NP_566546.1; NM_112511.4.
DR   PDB; 5GQT; X-ray; 3.02 A; A=1-470.
DR   PDBsum; 5GQT; -.
DR   AlphaFoldDB; Q9SDM9; -.
DR   SMR; Q9SDM9; -.
DR   BioGRID; 6221; 1.
DR   IntAct; Q9SDM9; 1.
DR   STRING; 3702.AT3G16400.1; -.
DR   iPTMnet; Q9SDM9; -.
DR   PaxDb; Q9SDM9; -.
DR   PRIDE; Q9SDM9; -.
DR   ProteomicsDB; 238971; -.
DR   EnsemblPlants; AT3G16400.1; AT3G16400.1; AT3G16400.
DR   EnsemblPlants; AT3G16400.2; AT3G16400.2; AT3G16400.
DR   GeneID; 820887; -.
DR   Gramene; AT3G16400.1; AT3G16400.1; AT3G16400.
DR   Gramene; AT3G16400.2; AT3G16400.2; AT3G16400.
DR   KEGG; ath:AT3G16400; -.
DR   Araport; AT3G16400; -.
DR   TAIR; locus:2088304; AT3G16400.
DR   eggNOG; KOG0379; Eukaryota.
DR   HOGENOM; CLU_030461_2_0_1; -.
DR   InParanoid; Q9SDM9; -.
DR   OMA; WKQCATP; -.
DR   OrthoDB; 933937at2759; -.
DR   PhylomeDB; Q9SDM9; -.
DR   PRO; PR:Q9SDM9; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9SDM9; baseline and differential.
DR   Genevisible; Q9SDM9; AT.
DR   GO; GO:0005829; C:cytosol; HDA:TAIR.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0030234; F:enzyme regulator activity; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; HDA:TAIR.
DR   GO; GO:0019762; P:glucosinolate catabolic process; IDA:TAIR.
DR   GO; GO:0080028; P:nitrile biosynthetic process; IDA:TAIR.
DR   GO; GO:0080027; P:response to herbivore; IMP:TAIR.
DR   CDD; cd09612; Jacalin; 1.
DR   Gene3D; 2.100.10.30; -; 1.
DR   Gene3D; 2.120.10.80; -; 1.
DR   InterPro; IPR001229; Jacalin-like_lectin_dom.
DR   InterPro; IPR033734; Jacalin-like_lectin_dom_plant.
DR   InterPro; IPR036404; Jacalin-like_lectin_dom_sf.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR035429; NSP1/2/3.
DR   Pfam; PF01419; Jacalin; 1.
DR   Pfam; PF01344; Kelch_1; 2.
DR   PIRSF; PIRSF038118; Myrosinase-db_jacalin; 1.
DR   SMART; SM00915; Jacalin; 1.
DR   SMART; SM00612; Kelch; 3.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF51101; SSF51101; 1.
DR   PROSITE; PS51752; JACALIN_LECTIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Kelch repeat; Lectin; Reference proteome; Repeat.
FT   CHAIN           1..470
FT                   /note="Nitrile-specifier protein 1"
FT                   /id="PRO_0000072797"
FT   DOMAIN          2..143
FT                   /note="Jacalin-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01088"
FT   REPEAT          47..93
FT                   /note="Kelch 1"
FT   REPEAT          177..225
FT                   /note="Kelch 2"
FT   REPEAT          230..276
FT                   /note="Kelch 3"
FT   REPEAT          280..329
FT                   /note="Kelch 4"
FT   REPEAT          331..375
FT                   /note="Kelch 5"
FT   CONFLICT        25
FT                   /note="R -> K (in Ref. 1; AAF25385)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        124
FT                   /note="V -> I (in Ref. 1; AAF25385)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        147
FT                   /note="I -> T (in Ref. 1; AAF25385 and 6; AAM64914)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        232
FT                   /note="Y -> C (in Ref. 7; BAF01186)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        376
FT                   /note="I -> L (in Ref. 1; AAF25385 and 6; AAM64914)"
FT                   /evidence="ECO:0000305"
FT   STRAND          13..17
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          22..31
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          33..45
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          48..51
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          63..67
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          74..82
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          91..99
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          104..106
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          112..118
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          123..141
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          152..156
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          170..174
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          177..181
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          184..186
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          195..199
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   TURN            200..203
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          204..207
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          220..227
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          230..237
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          246..250
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   TURN            251..254
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          255..260
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   TURN            262..264
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          269..271
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          273..276
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          278..284
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          287..290
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          296..300
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   TURN            301..304
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          305..308
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   HELIX           313..315
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          319..321
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          323..326
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          328..349
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   TURN            350..353
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          354..357
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          361..363
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          372..376
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          379..388
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          399..408
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   TURN            409..411
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          413..416
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          420..422
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          434..439
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          444..449
FT                   /evidence="ECO:0007829|PDB:5GQT"
FT   STRAND          462..466
FT                   /evidence="ECO:0007829|PDB:5GQT"
SQ   SEQUENCE   470 AA;  51670 MW;  A9527780362F0157 CRC64;
     MAQKLEAKGG EMGDVWDDGV YENVRKVYVG QAQYGIAFVK FEYVNGSQVV VGDEHGKKTE
     LGVEEFEIDA DDYIVYVEGY REKVNDMTSE MITFLSIKTF KGKTSHPIEK RPGVKFVLHG
     GKIVGFHGRS TDVLHSLGAY VSLSSTIKLL GKWIKVEQKG EGPGLRCSHG IAQVGNKIYS
     FGGEFTPNQP IDKHLYVFDL ETRTWSISPA TGDVPHLSCL GVRMVSVGST LYVFGGRDAS
     RQYNGFYSFD TTTNEWKLLT PVEEGPTPRS FHSMAADEEN VYVFGGVSAT ARLNTLDSYN
     IVDKKWFHCS TPGDSLTARG GAGLEVVQGK VWVVYGFNGC EVDDVHYYDP VQDKWTQVET
     FGVRPSERSV FASAAIGKHI VIFGGEIAMD PLAHVGPGQL TDGTFALDTE TLQWERLDKF
     GGEEETPSSR GWTASTTATI DGKKGLVMHG GKAPTNDRFD DLFFYGIDSA
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024