JANA_DROER
ID JANA_DROER Reviewed; 135 AA.
AC Q9BM97;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Sex-regulated protein janus-A;
GN Name=janA;
OS Drosophila erecta (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7220 {ECO:0000312|EMBL:AAG50364.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11319264; DOI=10.1093/oxfordjournals.molbev.a003862;
RA Parsch J., Meiklejohn C.D., Hauschteck-Jungen E., Hunziker P., Hartl D.L.;
RT "Molecular evolution of the ocnus and janus genes in the Drosophila
RT melanogaster species subgroup.";
RL Mol. Biol. Evol. 18:801-811(2001).
CC -!- FUNCTION: JanA and janB regulate somatic sex differentiation.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the janus family. {ECO:0000305}.
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DR EMBL; AY013343; AAG50364.1; -; Genomic_DNA.
DR RefSeq; XP_001981255.2; XM_001981219.2.
DR AlphaFoldDB; Q9BM97; -.
DR SMR; Q9BM97; -.
DR STRING; 7220.FBpp0130516; -.
DR EnsemblMetazoa; FBtr0132024; FBpp0130516; FBgn0043709.
DR GeneID; 6554365; -.
DR KEGG; der:6554365; -.
DR eggNOG; ENOG502S4DR; Eukaryota.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007548; P:sex differentiation; ISS:UniProtKB.
DR Gene3D; 3.50.20.20; -; 1.
DR InterPro; IPR007702; Janus.
DR InterPro; IPR038596; Janus_sf.
DR PANTHER; PTHR12258; PTHR12258; 1.
DR Pfam; PF05005; Ocnus; 1.
PE 3: Inferred from homology;
KW Differentiation; Sexual differentiation.
FT CHAIN 1..135
FT /note="Sex-regulated protein janus-A"
FT /id="PRO_0000206156"
FT ACT_SITE 63
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 37
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 104..106
FT /ligand="substrate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 135 AA; 15180 MW; DB294031FEDFD07C CRC64;
MNRFQLLSKG LRLIHKMSEE ALAGVPLVHI SPEGIFKYVM INVIDGGDAS KAVIRGFADC
TWHADIFDRE EEVFKKLGLR AECPGGGRIE HNPDKKYLKV YGYSQGFGKA DHAQTKRILA
TKYPDYTIET SDEGY