ID   JANA_DROMA              Reviewed;         135 AA.
AC   Q9BM98; Q9BH67; Q9BMZ5;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Sex-regulated protein janus-A;
GN   Name=janA;
OS   Drosophila mauritiana (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7226 {ECO:0000312|EMBL:AAG50361.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11319264; DOI=10.1093/oxfordjournals.molbev.a003862;
RA   Parsch J., Meiklejohn C.D., Hauschteck-Jungen E., Hunziker P., Hartl D.L.;
RT   "Molecular evolution of the ocnus and janus genes in the Drosophila
RT   melanogaster species subgroup.";
RL   Mol. Biol. Evol. 18:801-811(2001).
RN   [2] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 32-135.
RC   STRAIN=1631 {ECO:0000312|EMBL:AAG49472.1},
RC   Cap Malheureux {ECO:0000312|EMBL:AAG49474.1}, and
RC   Port-Louis {ECO:0000312|EMBL:AAG49476.1};
RX   PubMed=11102384; DOI=10.1093/genetics/156.4.1913;
RA   Kliman R.M., Andolfatto P., Coyne J.A., Depaulis F., Kreitman M.,
RA   Berry A.J., McCarter J., Wakeley J., Hey J.;
RT   "The population genetics of the origin and divergence of the Drosophila
RT   simulans complex species.";
RL   Genetics 156:1913-1931(2000).
CC   -!- FUNCTION: JanA and janB regulate somatic sex differentiation.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the janus family. {ECO:0000305}.
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DR   EMBL; AY013340; AAG50361.1; -; Genomic_DNA.
DR   EMBL; AF284456; AAG49472.1; -; Genomic_DNA.
DR   EMBL; AF284457; AAG49474.1; -; Genomic_DNA.
DR   EMBL; AF284458; AAG49476.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9BM98; -.
DR   SMR; Q9BM98; -.
DR   FlyBase; FBgn0043691; Dmau\janA.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007548; P:sex differentiation; ISS:UniProtKB.
DR   Gene3D; 3.50.20.20; -; 1.
DR   InterPro; IPR007702; Janus.
DR   InterPro; IPR038596; Janus_sf.
DR   PANTHER; PTHR12258; PTHR12258; 1.
DR   Pfam; PF05005; Ocnus; 1.
PE   3: Inferred from homology;
KW   Differentiation; Sexual differentiation.
FT   CHAIN           1..135
FT                   /note="Sex-regulated protein janus-A"
FT                   /id="PRO_0000206157"
FT   ACT_SITE        63
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         37
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         104..106
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        56
FT                   /note="G -> R (in Ref. 2; AAG49472/AAG49474/AAG49476)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        72
FT                   /note="D -> E (in Ref. 2; AAG49472/AAG49474/AAG49476)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   135 AA;  15158 MW;  2F91E387BD70C1CC CRC64;
     MNRLQLLSKG LRLIHKMSEE ALAGVPLVHI SPEGIFKYVM INVIDGGDAS KAVIRGFADC
     TWHADIFERE EDVFKKLGLR AECPGGGRIE HNPDKKYLKV YGYSQGFGKA DHAQTKRILA
     TKYPDYTIEI SDEGY