ID   JANA_DROPS              Reviewed;         149 AA.
AC   P54364; Q29C76;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 2.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Sex-regulated protein janus-A;
GN   Name=janA; ORFNames=GA20699;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7700229; DOI=10.1007/bf00298961;
RA   Yanicostas C., Ferrer P., Vincent A., Lepesant J.-A.;
RT   "Separate cis-regulatory sequences control expression of serendipity beta
RT   and janus A, two immediately adjacent Drosophila genes.";
RL   Mol. Gen. Genet. 246:549-560(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: JanA and janB regulate somatic sex differentiation.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the janus family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB33912.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=EAL26770.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; S77099; AAB33912.2; ALT_SEQ; Genomic_DNA.
DR   EMBL; CM000070; EAL26770.2; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_003736221.1; XM_003736173.2.
DR   AlphaFoldDB; P54364; -.
DR   SMR; P54364; -.
DR   STRING; 7237.FBpp0292169; -.
DR   EnsemblMetazoa; FBtr0303050; FBpp0292169; FBgn0015151.
DR   GeneID; 4800256; -.
DR   KEGG; dpo:Dpse_GA20699; -.
DR   eggNOG; ENOG502S4DR; Eukaryota.
DR   InParanoid; P54364; -.
DR   OMA; MCTQTRA; -.
DR   Proteomes; UP000001819; Chromosome 2.
DR   Bgee; FBgn0015151; Expressed in female reproductive system and 2 other tissues.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007548; P:sex differentiation; ISS:UniProtKB.
DR   Gene3D; 3.50.20.20; -; 1.
DR   InterPro; IPR007702; Janus.
DR   InterPro; IPR038596; Janus_sf.
DR   PANTHER; PTHR12258; PTHR12258; 1.
DR   Pfam; PF05005; Ocnus; 1.
PE   3: Inferred from homology;
KW   Differentiation; Reference proteome; Sexual differentiation.
FT   CHAIN           1..149
FT                   /note="Sex-regulated protein janus-A"
FT                   /id="PRO_0000206160"
FT   ACT_SITE        77
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         46
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         118..120
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   149 AA;  16744 MW;  4D74D5A2FB0DA978 CRC64;
     MLKAAAAALY RKNSNFLQGL RLLHKMSDQD LAKIPLVDID EEGIFKYILI RVTGKETADG
     TEPSKLVVRG YADCEWHADI YERTQGTIKG TGLDTECLGG GRIEHNPEKK YLKVYGHSTG
     YGKADHAESK RVLLTKYKNY EIETSDEGY