JANA_DROSI
ID JANA_DROSI Reviewed; 135 AA.
AC Q9BM99; Q5Y7Z5; Q95VY7; Q9BH68; Q9BMZ7;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Sex-regulated protein janus-A;
GN Name=janA;
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240 {ECO:0000312|EMBL:AAK72008.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11319264; DOI=10.1093/oxfordjournals.molbev.a003862;
RA Parsch J., Meiklejohn C.D., Hauschteck-Jungen E., Hunziker P., Hartl D.L.;
RT "Molecular evolution of the ocnus and janus genes in the Drosophila
RT melanogaster species subgroup.";
RL Mol. Biol. Evol. 18:801-811(2001).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=s17 {ECO:0000312|EMBL:AAK72015.1},
RC s19 {ECO:0000312|EMBL:AAK72016.1}, s2 {ECO:0000312|EMBL:AAK72008.1},
RC s25 {ECO:0000312|EMBL:AAK72017.1}, s3 {ECO:0000312|EMBL:AAK72009.1},
RC s31 {ECO:0000312|EMBL:AAK72018.1}, s34 {ECO:0000312|EMBL:AAK72019.1},
RC s36 {ECO:0000312|EMBL:AAK72020.1}, s4 {ECO:0000312|EMBL:AAK72010.1},
RC s5 {ECO:0000312|EMBL:AAK72011.1}, s6 {ECO:0000312|EMBL:AAK72012.1},
RC s7 {ECO:0000312|EMBL:AAK72013.1}, and s8 {ECO:0000312|EMBL:AAK72014.1};
RX PubMed=11606541; DOI=10.1093/genetics/159.2.647;
RA Parsch J., Meiklejohn C.D., Hartl D.L.;
RT "Patterns of DNA sequence variation suggest the recent action of positive
RT selection in the janus-ocnus region of Drosophila simulans.";
RL Genetics 159:647-657(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=S10, S11, S12, S13, S14, S15, S16, S18, S20, S21, S22, S23, S24,
RC S26, S27, S28, S29, S30, S32, S33, S35, and S9;
RX PubMed=15454542; DOI=10.1534/genetics.103.025494;
RA Meiklejohn C.D., Kim Y., Hartl D.L., Parsch J.;
RT "Identification of a locus under complex positive selection in Drosophila
RT simulans by haplotype mapping and composite-likelihood estimation.";
RL Genetics 168:265-279(2004).
RN [4] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-135.
RC STRAIN=kenya_12 {ECO:0000312|EMBL:AAG49470.1},
RC kenya_2 {ECO:0000312|EMBL:AAG49466.1}, and
RC kenya_5 {ECO:0000312|EMBL:AAG49468.1};
RX PubMed=11102384; DOI=10.1093/genetics/156.4.1913;
RA Kliman R.M., Andolfatto P., Coyne J.A., Depaulis F., Kreitman M.,
RA Berry A.J., McCarter J., Wakeley J., Hey J.;
RT "The population genetics of the origin and divergence of the Drosophila
RT simulans complex species.";
RL Genetics 156:1913-1931(2000).
CC -!- FUNCTION: JanA and janB regulate somatic sex differentiation.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the janus family. {ECO:0000305}.
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DR EMBL; AY013339; AAG50360.1; -; Genomic_DNA.
DR EMBL; AF393330; AAK72008.1; -; Genomic_DNA.
DR EMBL; AF393331; AAK72009.1; -; Genomic_DNA.
DR EMBL; AF393332; AAK72010.1; -; Genomic_DNA.
DR EMBL; AF393333; AAK72011.1; -; Genomic_DNA.
DR EMBL; AF393334; AAK72012.1; -; Genomic_DNA.
DR EMBL; AF393335; AAK72013.1; -; Genomic_DNA.
DR EMBL; AF393336; AAK72014.1; -; Genomic_DNA.
DR EMBL; AF393337; AAK72015.1; -; Genomic_DNA.
DR EMBL; AF393338; AAK72016.1; -; Genomic_DNA.
DR EMBL; AF393339; AAK72017.1; -; Genomic_DNA.
DR EMBL; AF393340; AAK72018.1; -; Genomic_DNA.
DR EMBL; AF393341; AAK72019.1; -; Genomic_DNA.
DR EMBL; AF393342; AAK72020.1; -; Genomic_DNA.
DR EMBL; AY663111; AAU81681.1; -; Genomic_DNA.
DR EMBL; AY663112; AAU81682.1; -; Genomic_DNA.
DR EMBL; AY663113; AAU81683.1; -; Genomic_DNA.
DR EMBL; AY663114; AAU81684.1; -; Genomic_DNA.
DR EMBL; AY663115; AAU81685.1; -; Genomic_DNA.
DR EMBL; AY663116; AAU81686.1; -; Genomic_DNA.
DR EMBL; AY663117; AAU81687.1; -; Genomic_DNA.
DR EMBL; AY663118; AAU81688.1; -; Genomic_DNA.
DR EMBL; AY663119; AAU81689.1; -; Genomic_DNA.
DR EMBL; AY663120; AAU81690.1; -; Genomic_DNA.
DR EMBL; AY663121; AAU81691.1; -; Genomic_DNA.
DR EMBL; AY663122; AAU81692.1; -; Genomic_DNA.
DR EMBL; AY663123; AAU81693.1; -; Genomic_DNA.
DR EMBL; AY663124; AAU81694.1; -; Genomic_DNA.
DR EMBL; AY663125; AAU81695.1; -; Genomic_DNA.
DR EMBL; AY663126; AAU81696.1; -; Genomic_DNA.
DR EMBL; AY663127; AAU81697.1; -; Genomic_DNA.
DR EMBL; AY663128; AAU81698.1; -; Genomic_DNA.
DR EMBL; AY663129; AAU81699.1; -; Genomic_DNA.
DR EMBL; AY663130; AAU81700.1; -; Genomic_DNA.
DR EMBL; AY663131; AAU81701.1; -; Genomic_DNA.
DR EMBL; AY663132; AAU81702.1; -; Genomic_DNA.
DR EMBL; AF284453; AAG49466.1; -; Genomic_DNA.
DR EMBL; AF284454; AAG49468.1; -; Genomic_DNA.
DR EMBL; AF284455; AAG49470.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9BM99; -.
DR SMR; Q9BM99; -.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007548; P:sex differentiation; ISS:UniProtKB.
DR Gene3D; 3.50.20.20; -; 1.
DR InterPro; IPR007702; Janus.
DR InterPro; IPR038596; Janus_sf.
DR PANTHER; PTHR12258; PTHR12258; 1.
DR Pfam; PF05005; Ocnus; 1.
PE 3: Inferred from homology;
KW Differentiation; Sexual differentiation.
FT CHAIN 1..135
FT /note="Sex-regulated protein janus-A"
FT /id="PRO_0000206161"
FT ACT_SITE 63
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 37
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 104..106
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT VARIANT 17
FT /note="M -> L (in strain: s2)"
FT /evidence="ECO:0000269|PubMed:11606541"
FT CONFLICT 56
FT /note="G -> R (in Ref. 4; AAG49466/AAG49468/AAG49470)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 135 AA; 15206 MW; 2E2940304F7E21CD CRC64;
MNRFQLLSKG LRLIHKMSEE ALAGVPLVHI SPEGIFKYVM INVIDGGDAS KAVIRGFADC
TWHADIFERE EEVFKKLGLR AECPGGGRIE HNPDKKYLKV YGYSQGFGKA DHAQTKRILA
TKYPDYTIEI SDEGY
