ID   JANA_DROYA              Reviewed;         135 AA.
AC   P83753; Q9BH48;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   02-FEB-2004, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Sex-regulated protein janus-A;
GN   Name=janA;
OS   Drosophila yakuba (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7245 {ECO:0000312|EMBL:AAG50362.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11319264; DOI=10.1093/oxfordjournals.molbev.a003862;
RA   Parsch J., Meiklejohn C.D., Hauschteck-Jungen E., Hunziker P., Hartl D.L.;
RT   "Molecular evolution of the ocnus and janus genes in the Drosophila
RT   melanogaster species subgroup.";
RL   Mol. Biol. Evol. 18:801-811(2001).
CC   -!- FUNCTION: JanA and janB regulate somatic sex differentiation.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the janus family. {ECO:0000305}.
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DR   EMBL; AY013341; AAG50362.1; -; Genomic_DNA.
DR   AlphaFoldDB; P83753; -.
DR   SMR; P83753; -.
DR   STRING; 7245.FBpp0268429; -.
DR   eggNOG; ENOG502S4DR; Eukaryota.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007548; P:sex differentiation; ISS:UniProtKB.
DR   Gene3D; 3.50.20.20; -; 1.
DR   InterPro; IPR007702; Janus.
DR   InterPro; IPR038596; Janus_sf.
DR   PANTHER; PTHR12258; PTHR12258; 1.
DR   Pfam; PF05005; Ocnus; 1.
PE   3: Inferred from homology;
KW   Differentiation; Sexual differentiation.
FT   CHAIN           1..135
FT                   /note="Sex-regulated protein janus-A"
FT                   /id="PRO_0000206163"
FT   ACT_SITE        63
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         37
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         104..106
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   135 AA;  15206 MW;  C1756A84DE05671C CRC64;
     MNRLQLFSKG LRLIHKMSEE ALAGVPLVHI SPEGIFKYVL INVIDGGDAS KAVVRGFDDC
     TWHADIFDRE EEVFKKLGLR AECPGGGRIE HNPEKKYLKV YGYSQGFGKA DHAQTKRILA
     TKYPDYTIET SDEGY