ID   JANB_DROER              Reviewed;         140 AA.
AC   Q9BM90; B3P7Z9;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Sex-regulated protein janus-B;
GN   Name=janB; ORFNames=GG11971;
OS   Drosophila erecta (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7220 {ECO:0000312|EMBL:AAG50371.1};
RN   [1] {ECO:0000312|EMBL:AAG50371.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11319264; DOI=10.1093/oxfordjournals.molbev.a003862;
RA   Parsch J., Meiklejohn C.D., Hauschteck-Jungen E., Hunziker P., Hartl D.L.;
RT   "Molecular evolution of the ocnus and janus genes in the Drosophila
RT   melanogaster species subgroup.";
RL   Mol. Biol. Evol. 18:801-811(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14021-0224.01;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: JanA and janB regulate somatic sex differentiation.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the janus family. {ECO:0000305}.
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DR   EMBL; AY013350; AAG50371.1; -; Genomic_DNA.
DR   EMBL; CH954182; EDV53126.1; -; Genomic_DNA.
DR   RefSeq; XP_001981256.1; XM_001981220.2.
DR   AlphaFoldDB; Q9BM90; -.
DR   SMR; Q9BM90; -.
DR   EnsemblMetazoa; FBtr0132025; FBpp0130517; FBgn0043708.
DR   GeneID; 6554366; -.
DR   KEGG; der:6554366; -.
DR   HOGENOM; CLU_120717_1_0_1; -.
DR   OMA; WTTYKDF; -.
DR   OrthoDB; 1529401at2759; -.
DR   PhylomeDB; Q9BM90; -.
DR   Proteomes; UP000008711; Unassembled WGS sequence.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007548; P:sex differentiation; ISS:UniProtKB.
DR   Gene3D; 3.50.20.20; -; 1.
DR   InterPro; IPR007702; Janus.
DR   InterPro; IPR038596; Janus_sf.
DR   PANTHER; PTHR12258; PTHR12258; 1.
DR   Pfam; PF05005; Ocnus; 1.
PE   3: Inferred from homology;
KW   Differentiation; Sexual differentiation.
FT   CHAIN           1..140
FT                   /note="Sex-regulated protein janus-B"
FT                   /id="PRO_0000206164"
FT   ACT_SITE        69
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         42
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         110..112
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   140 AA;  15934 MW;  16A4C759A8FC3815 CRC64;
     MKMFQSLSLL PRIVSPFRKC YSTDLISLVG VPRVKITKGQ NRYLLVNIHT HGFTKYGRVI
     VRGADVENHL TIFDSILEEL EPQGICAKIL GGGRILNETD SKKMKIYGTS RTFGSADHTR
     TRNILQSWTT YKDFKITVKN