JANB_DROME
ID JANB_DROME Reviewed; 140 AA.
AC P20349; A0ANH4; A0ANH5; A0ANH6; A0ANH7; A0ANH8; A0ANI2; Q9VAB7;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Sex-regulated protein janus-B;
GN Name=janB; ORFNames=CG7931;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=Canton-S;
RX PubMed=2503707; DOI=10.1128/mcb.9.6.2526-2535.1989;
RA Yanicostas C., Vincent A., Lepesant J.-A.;
RT "Transcriptional and posttranscriptional regulation contributes to the sex-
RT regulated expression of two sequence-related genes at the janus locus of
RT Drosophila melanogaster.";
RL Mol. Cell. Biol. 9:2526-2535(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ZBMEL131, ZBMEL145, ZBMEL157, ZBMEL186, ZBMEL191, ZBMEL229,
RC ZBMEL377, ZBMEL384, ZBMEL398, ZBMEL82, ZBMEL84, and ZBMEL95;
RX PubMed=16951084; DOI=10.1534/genetics.106.058008;
RA Proeschel M., Zhang Z., Parsch J.;
RT "Widespread adaptive evolution of Drosophila genes with sex-biased
RT expression.";
RL Genetics 174:893-900(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- FUNCTION: JanA and janB regulate somatic sex differentiation.
CC {ECO:0000269|PubMed:2503707}.
CC -!- TISSUE SPECIFICITY: Germline cells of adult males.
CC -!- DEVELOPMENTAL STAGE: From the third-instar larval stage to the adult
CC stage.
CC -!- SIMILARITY: Belongs to the janus family. {ECO:0000305}.
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DR EMBL; M27033; AAC34204.1; -; Genomic_DNA.
DR EMBL; AM294212; CAL26116.1; -; Genomic_DNA.
DR EMBL; AM294213; CAL26117.1; -; Genomic_DNA.
DR EMBL; AM294214; CAL26118.1; -; Genomic_DNA.
DR EMBL; AM294215; CAL26119.1; -; Genomic_DNA.
DR EMBL; AM294216; CAL26120.1; -; Genomic_DNA.
DR EMBL; AM294217; CAL26121.1; -; Genomic_DNA.
DR EMBL; AM294218; CAL26122.1; -; Genomic_DNA.
DR EMBL; AM294219; CAL26123.1; -; Genomic_DNA.
DR EMBL; AM294220; CAL26124.1; -; Genomic_DNA.
DR EMBL; AM294221; CAL26125.1; -; Genomic_DNA.
DR EMBL; AM294222; CAL26126.1; -; Genomic_DNA.
DR EMBL; AM294223; CAL26127.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF56997.3; -; Genomic_DNA.
DR PIR; B32317; B32317.
DR RefSeq; NP_476584.2; NM_057236.5.
DR AlphaFoldDB; P20349; -.
DR SMR; P20349; -.
DR DIP; DIP-23986N; -.
DR IntAct; P20349; 2.
DR STRING; 7227.FBpp0084963; -.
DR PaxDb; P20349; -.
DR DNASU; 43568; -.
DR EnsemblMetazoa; FBtr0085598; FBpp0084963; FBgn0001281.
DR GeneID; 43568; -.
DR KEGG; dme:Dmel_CG7931; -.
DR CTD; 43568; -.
DR FlyBase; FBgn0001281; janB.
DR VEuPathDB; VectorBase:FBgn0001281; -.
DR GeneTree; ENSGT00390000002738; -.
DR HOGENOM; CLU_120717_1_0_1; -.
DR InParanoid; P20349; -.
DR OMA; WTTYKDF; -.
DR OrthoDB; 1529401at2759; -.
DR PhylomeDB; P20349; -.
DR BioGRID-ORCS; 43568; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 43568; -.
DR PRO; PR:P20349; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0001281; Expressed in testis and 11 other tissues.
DR ExpressionAtlas; P20349; baseline and differential.
DR Genevisible; P20349; DM.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0101006; F:protein histidine phosphatase activity; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0035971; P:peptidyl-histidine dephosphorylation; IBA:GO_Central.
DR GO; GO:0007548; P:sex differentiation; IEP:UniProtKB.
DR Gene3D; 3.50.20.20; -; 1.
DR InterPro; IPR007702; Janus.
DR InterPro; IPR038596; Janus_sf.
DR PANTHER; PTHR12258; PTHR12258; 1.
DR Pfam; PF05005; Ocnus; 1.
PE 2: Evidence at transcript level;
KW Differentiation; Reference proteome; Sexual differentiation.
FT CHAIN 1..140
FT /note="Sex-regulated protein janus-B"
FT /id="PRO_0000206166"
FT ACT_SITE 69
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 42
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 110..112
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT VARIANT 49
FT /note="H -> N (in strain: ZBMEL131)"
FT VARIANT 70
FT /note="L -> M (in strain: ZBMEL145 and ZBMEL186)"
FT VARIANT 99..100
FT /note="AE -> ED (in strain: ZBMEL84)"
FT VARIANT 119
FT /note="T -> A (in strain: ZBMEL95)"
FT VARIANT 139
FT /note="K -> T (in strain: ZBMEL229)"
SQ SEQUENCE 140 AA; 15860 MW; 5750CC28BB61D7FE CRC64;
MKMFKSLRLL PHIVSPFQKC YSTDLISLVG VPRVKITKGQ NRYLLVNIHT HGFTKYGRVI
VRGADVDNHL AVFDSILEEL EPEGICAKIL GGGRILNEAE NKKIKIYGTS RTFGGADHTR
TRNILQAWTT YKDFKITVKQ
