ID   JANB_DROPS              Reviewed;         140 AA.
AC   P54365; Q29C77;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 2.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Sex-regulated protein janus-B;
GN   Name=janB; ORFNames=GA20697;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7700229; DOI=10.1007/bf00298961;
RA   Yanicostas C., Ferrer P., Vincent A., Lepesant J.-A.;
RT   "Separate cis-regulatory sequences control expression of serendipity beta
RT   and janus A, two immediately adjacent Drosophila genes.";
RL   Mol. Gen. Genet. 246:549-560(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: JanA and janB regulate somatic sex differentiation.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the janus family. {ECO:0000305}.
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DR   EMBL; S77099; AAB33913.2; -; Genomic_DNA.
DR   EMBL; CM000070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; S53877; S53877.
DR   AlphaFoldDB; P54365; -.
DR   SMR; P54365; -.
DR   STRING; 7237.FBpp0291192; -.
DR   eggNOG; ENOG502T83H; Eukaryota.
DR   InParanoid; P54365; -.
DR   Proteomes; UP000001819; Genome assembly.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007548; P:sex differentiation; ISS:UniProtKB.
DR   Gene3D; 3.50.20.20; -; 1.
DR   InterPro; IPR007702; Janus.
DR   InterPro; IPR038596; Janus_sf.
DR   PANTHER; PTHR12258; PTHR12258; 1.
DR   Pfam; PF05005; Ocnus; 1.
PE   3: Inferred from homology;
KW   Differentiation; Reference proteome; Sexual differentiation.
FT   CHAIN           1..140
FT                   /note="Sex-regulated protein janus-B"
FT                   /id="PRO_0000206168"
FT   ACT_SITE        69
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         42
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         110..112
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        105
FT                   /note="K -> E (in Ref. 1; AAB33913)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   140 AA;  15812 MW;  01B87FE95225D53A CRC64;
     MKILNCFSLI GQCAKPILRT YTSPAADLLK LPRVDIKEGK LRYLLLSVYI HGETKHARTV
     VRGWNTDSHD DIYYKNVRAM EKLGLCTKCL GGGKMDNDES ARKIKIHGSC KTFGAANHHK
     TKEILLSSSK YKNFNITVKK