ID   JANB_DROSE              Reviewed;         140 AA.
AC   Q9BM94; B4HZK6; Q9BMZ0;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Sex-regulated protein janus-B;
GN   Name=janB; ORFNames=GM12188;
OS   Drosophila sechellia (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7238 {ECO:0000312|EMBL:AAG50367.1};
RN   [1] {ECO:0000312|EMBL:AAG50367.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11319264; DOI=10.1093/oxfordjournals.molbev.a003862;
RA   Parsch J., Meiklejohn C.D., Hauschteck-Jungen E., Hunziker P., Hartl D.L.;
RT   "Molecular evolution of the ocnus and janus genes in the Drosophila
RT   melanogaster species subgroup.";
RL   Mol. Biol. Evol. 18:801-811(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rob3c / Tucson 14021-0248.25;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
RN   [3] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-76.
RC   STRAIN=228 {ECO:0000312|EMBL:AAG49479.1};
RX   PubMed=11102384; DOI=10.1093/genetics/156.4.1913;
RA   Kliman R.M., Andolfatto P., Coyne J.A., Depaulis F., Kreitman M.,
RA   Berry A.J., McCarter J., Wakeley J., Hey J.;
RT   "The population genetics of the origin and divergence of the Drosophila
RT   simulans complex species.";
RL   Genetics 156:1913-1931(2000).
CC   -!- FUNCTION: JanA and janB regulate somatic sex differentiation.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the janus family. {ECO:0000305}.
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DR   EMBL; AY013346; AAG50367.1; -; Genomic_DNA.
DR   EMBL; CH480819; EDW53463.1; -; Genomic_DNA.
DR   EMBL; AF284459; AAG49479.1; -; Genomic_DNA.
DR   RefSeq; XP_002037304.1; XM_002037268.1.
DR   AlphaFoldDB; Q9BM94; -.
DR   SMR; Q9BM94; -.
DR   EnsemblMetazoa; FBtr0195173; FBpp0193665; FBgn0043636.
DR   GeneID; 6612803; -.
DR   KEGG; dse:6612803; -.
DR   HOGENOM; CLU_120717_1_0_1; -.
DR   OMA; WTTYKDF; -.
DR   PhylomeDB; Q9BM94; -.
DR   Proteomes; UP000001292; Unassembled WGS sequence.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007548; P:sex differentiation; ISS:UniProtKB.
DR   Gene3D; 3.50.20.20; -; 1.
DR   InterPro; IPR007702; Janus.
DR   InterPro; IPR038596; Janus_sf.
DR   PANTHER; PTHR12258; PTHR12258; 1.
DR   Pfam; PF05005; Ocnus; 1.
PE   3: Inferred from homology;
KW   Differentiation; Reference proteome; Sexual differentiation.
FT   CHAIN           1..140
FT                   /note="Sex-regulated protein janus-B"
FT                   /id="PRO_0000206169"
FT   ACT_SITE        69
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         42
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         110..112
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   140 AA;  15787 MW;  F55705D486D6301A CRC64;
     MKMLKSLSLI PRIVSPFQKC YSTDLISLVG VPRVKISKGQ NRYLLVNIHT HGFTKYGRVI
     VRGADVDNHL AIFDSILEEL EPEGICAKIL GGGRILNEPD NKKIKIYGTS RTFGGADHTR
     TRNILQAWTT YKDFKITVKQ