JANB_DROSI
ID JANB_DROSI Reviewed; 140 AA.
AC Q9BM95; Q5Y7X3; Q9BH62; Q9BMZ6;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Sex-regulated protein janus-B;
GN Name=janB;
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240 {ECO:0000312|EMBL:AAG50366.1};
RN [1] {ECO:0000312|EMBL:AAG50366.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11319264; DOI=10.1093/oxfordjournals.molbev.a003862;
RA Parsch J., Meiklejohn C.D., Hauschteck-Jungen E., Hunziker P., Hartl D.L.;
RT "Molecular evolution of the ocnus and janus genes in the Drosophila
RT melanogaster species subgroup.";
RL Mol. Biol. Evol. 18:801-811(2001).
RN [2] {ECO:0000312|EMBL:AAK72033.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=s17 {ECO:0000312|EMBL:AAK72028.1},
RC s19 {ECO:0000312|EMBL:AAK72029.1}, s2 {ECO:0000312|EMBL:AAK72021.1},
RC s25 {ECO:0000312|EMBL:AAK72030.1}, s3 {ECO:0000312|EMBL:AAK72022.1},
RC s31 {ECO:0000312|EMBL:AAK72031.1}, s34 {ECO:0000312|EMBL:AAK72032.1},
RC s36 {ECO:0000312|EMBL:AAK72033.1}, s4 {ECO:0000312|EMBL:AAK72023.1},
RC s5 {ECO:0000312|EMBL:AAK72024.1}, s6 {ECO:0000312|EMBL:AAK72025.1},
RC s7 {ECO:0000312|EMBL:AAK72026.1}, and s8 {ECO:0000312|EMBL:AAK72027.1};
RX PubMed=11606541; DOI=10.1093/genetics/159.2.647;
RA Parsch J., Meiklejohn C.D., Hartl D.L.;
RT "Patterns of DNA sequence variation suggest the recent action of positive
RT selection in the janus-ocnus region of Drosophila simulans.";
RL Genetics 159:647-657(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=S10, S11, S12, S13, S14, S15, S16, S18, S20, S21, S22, S23, S24,
RC S26, S27, S28, S29, S30, S32, S33, S35, and S9;
RX PubMed=15454542; DOI=10.1534/genetics.103.025494;
RA Meiklejohn C.D., Kim Y., Hartl D.L., Parsch J.;
RT "Identification of a locus under complex positive selection in Drosophila
RT simulans by haplotype mapping and composite-likelihood estimation.";
RL Genetics 168:265-279(2004).
RN [4] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-76.
RC STRAIN=kenya_12 {ECO:0000312|EMBL:AAG49471.1},
RC kenya_2 {ECO:0000312|EMBL:AAG49467.1}, and
RC kenya_5 {ECO:0000312|EMBL:AAG49469.1};
RX PubMed=11102384; DOI=10.1093/genetics/156.4.1913;
RA Kliman R.M., Andolfatto P., Coyne J.A., Depaulis F., Kreitman M.,
RA Berry A.J., McCarter J., Wakeley J., Hey J.;
RT "The population genetics of the origin and divergence of the Drosophila
RT simulans complex species.";
RL Genetics 156:1913-1931(2000).
CC -!- FUNCTION: JanA and janB regulate somatic sex differentiation.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the janus family. {ECO:0000305}.
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DR EMBL; AY013345; AAG50366.1; -; Genomic_DNA.
DR EMBL; AF393343; AAK72021.1; -; Genomic_DNA.
DR EMBL; AF393344; AAK72022.1; -; Genomic_DNA.
DR EMBL; AF393345; AAK72023.1; -; Genomic_DNA.
DR EMBL; AF393346; AAK72024.1; -; Genomic_DNA.
DR EMBL; AF393347; AAK72025.1; -; Genomic_DNA.
DR EMBL; AF393348; AAK72026.1; -; Genomic_DNA.
DR EMBL; AF393349; AAK72027.1; -; Genomic_DNA.
DR EMBL; AF393350; AAK72028.1; -; Genomic_DNA.
DR EMBL; AF393351; AAK72029.1; -; Genomic_DNA.
DR EMBL; AF393352; AAK72030.1; -; Genomic_DNA.
DR EMBL; AF393353; AAK72031.1; -; Genomic_DNA.
DR EMBL; AF393354; AAK72032.1; -; Genomic_DNA.
DR EMBL; AF393355; AAK72033.1; -; Genomic_DNA.
DR EMBL; AY663133; AAU44623.1; -; Genomic_DNA.
DR EMBL; AY663134; AAU44624.1; -; Genomic_DNA.
DR EMBL; AY663135; AAU44625.1; -; Genomic_DNA.
DR EMBL; AY663136; AAU44626.1; -; Genomic_DNA.
DR EMBL; AY663137; AAU44627.1; -; Genomic_DNA.
DR EMBL; AY663138; AAU44628.1; -; Genomic_DNA.
DR EMBL; AY663139; AAU44629.1; -; Genomic_DNA.
DR EMBL; AY663140; AAU44630.1; -; Genomic_DNA.
DR EMBL; AY663141; AAU44631.1; -; Genomic_DNA.
DR EMBL; AY663142; AAU44632.1; -; Genomic_DNA.
DR EMBL; AY663143; AAU44633.1; -; Genomic_DNA.
DR EMBL; AY663144; AAU44634.1; -; Genomic_DNA.
DR EMBL; AY663145; AAU44635.1; -; Genomic_DNA.
DR EMBL; AY663146; AAU44636.1; -; Genomic_DNA.
DR EMBL; AY663147; AAU44637.1; -; Genomic_DNA.
DR EMBL; AY663148; AAU44638.1; -; Genomic_DNA.
DR EMBL; AY663149; AAU44639.1; -; Genomic_DNA.
DR EMBL; AY663150; AAU44640.1; -; Genomic_DNA.
DR EMBL; AY663151; AAU44641.1; -; Genomic_DNA.
DR EMBL; AY663152; AAU44642.1; -; Genomic_DNA.
DR EMBL; AY663153; AAU44643.1; -; Genomic_DNA.
DR EMBL; AY663154; AAU44644.1; -; Genomic_DNA.
DR EMBL; AF284453; AAG49467.1; -; Genomic_DNA.
DR EMBL; AF284454; AAG49469.1; -; Genomic_DNA.
DR EMBL; AF284455; AAG49471.1; -; Genomic_DNA.
DR RefSeq; XP_002105454.2; XM_002105418.2.
DR AlphaFoldDB; Q9BM95; -.
DR SMR; Q9BM95; -.
DR EnsemblMetazoa; FBtr0217320; FBpp0215812; FBgn0041268.
DR GeneID; 6730163; -.
DR Bgee; FBgn0041268; Expressed in male reproductive system and 3 other tissues.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007548; P:sex differentiation; ISS:UniProtKB.
DR Gene3D; 3.50.20.20; -; 1.
DR InterPro; IPR007702; Janus.
DR InterPro; IPR038596; Janus_sf.
DR PANTHER; PTHR12258; PTHR12258; 1.
DR Pfam; PF05005; Ocnus; 1.
PE 3: Inferred from homology;
KW Differentiation; Sexual differentiation.
FT CHAIN 1..140
FT /note="Sex-regulated protein janus-B"
FT /id="PRO_0000206170"
FT ACT_SITE 69
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 42
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 110..112
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT VARIANT 27
FT /note="N -> S (in strain: kenya_2)"
FT /evidence="ECO:0000269|PubMed:11102384"
FT VARIANT 72
FT /note="I -> V (in strain: kenya_2)"
FT /evidence="ECO:0000269|PubMed:11102384"
SQ SEQUENCE 140 AA; 15863 MW; E0FC49F05DBD3E1E CRC64;
MKMFKSLSLI PRIVSPFQKC YSTDLINLVG VPRVKITKGQ NRYLLVNIHT HGFTKYGRVI
VRGADVDNHL AIFDSILEEL EPEGICAKIL GGGRILNEPD NKKIKIYGTS RTFGGADHTR
TRNILQAWTT YKDFKITVKQ
