JAZF1_MOUSE
ID JAZF1_MOUSE Reviewed; 243 AA.
AC Q80ZQ5; Q8BLQ8; Q8BWN4;
DT 11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2003, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Juxtaposed with another zinc finger protein 1;
GN Name=Jazf1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain cortex, and Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-109 AND THR-113, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=24380856; DOI=10.1016/j.bbrc.2013.12.094;
RA Jang W.Y., Bae K.B., Kim S.H., Yu D.H., Kim H.J., Ji Y.R., Park S.J.,
RA Park S.J., Kang M.C., Jeong J.I., Park S.J., Lee S.G., Lee I., Kim M.O.,
RA Yoon D., Ryoo Z.Y.;
RT "Overexpression of Jazf1 reduces body weight gain and regulates lipid
RT metabolism in high fat diet.";
RL Biochem. Biophys. Res. Commun. 444:296-301(2014).
RN [5]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=24930994; DOI=10.1016/j.metabol.2014.05.006;
RA Ming G.F., Li X., Yin J.Y., Ai Y.H., Xu D.M., Ma X.H., Liu Z.Y., Liu H.X.,
RA Zhou H.H., Liu Z.Q.;
RT "JAZF1 regulates visfatin expression in adipocytes via PPARalpha and
RT PPARbeta/delta signaling.";
RL Metabolism 63:1012-1021(2014).
RN [6]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=25614086; DOI=10.1038/ijo.2015.5;
RA Yuan L., Luo X., Zeng M., Zhang Y., Yang M., Zhang L., Liu R., Boden G.,
RA Liu H., Ma Z.A., Li L., Yang G.;
RT "Transcription factor TIP27 regulates glucose homeostasis and insulin
RT sensitivity in a PI3-kinase/Akt-dependent manner in mice.";
RL Int. J. Obes. Relat. Metab. Disord. 39:949-958(2015).
CC -!- FUNCTION: Acts as a transcriptional corepressor of orphan nuclear
CC receptor NR2C2 (By similarity). Inhibits expression of the
CC gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity
CC (PubMed:24380856). Also involved in transcriptional activation of NAMPT
CC by promoting expression of PPARA and PPARD (PubMed:24930994). Plays a
CC role in lipid metabolism by suppressing lipogenesis, increasing
CC lipolysis and decreasing lipid accumulation in adipose tissue
CC (PubMed:24380856, PubMed:25614086). Plays a role in glucose homeostasis
CC by improving glucose metabolism and insulin sensitivity
CC (PubMed:25614086, PubMed:24380856). {ECO:0000250|UniProtKB:Q86VZ6,
CC ECO:0000269|PubMed:24380856, ECO:0000269|PubMed:24930994,
CC ECO:0000269|PubMed:25614086}.
CC -!- SUBUNIT: Interacts with NR2C2 (via ligand-binding region).
CC {ECO:0000250|UniProtKB:Q86VZ6}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q86VZ6}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q80ZQ5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q80ZQ5-2; Sequence=VSP_007756;
CC -!- TISSUE SPECIFICITY: Expressed in range of tissues with highest
CC expression levels in testis, liver, muscle and fat and lowest levels in
CC kidney (PubMed:25614086). Detected in liver and white adipose tissue
CC (at protein level) (PubMed:24380856). {ECO:0000269|PubMed:24380856,
CC ECO:0000269|PubMed:25614086}.
CC -!- DEVELOPMENTAL STAGE: Expression is gradually but significantly up-
CC regulated during adipocyte differentiation.
CC {ECO:0000269|PubMed:24930994}.
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DR EMBL; AK043767; BAC31649.1; -; mRNA.
DR EMBL; AK050474; BAC34275.1; -; mRNA.
DR EMBL; BC048577; AAH48577.1; -; mRNA.
DR CCDS; CCDS20152.1; -. [Q80ZQ5-1]
DR RefSeq; NP_001161749.1; NM_001168277.1.
DR RefSeq; NP_775582.2; NM_173406.3. [Q80ZQ5-1]
DR RefSeq; XP_011239597.1; XM_011241295.2.
DR AlphaFoldDB; Q80ZQ5; -.
DR STRING; 10090.ENSMUSP00000074129; -.
DR iPTMnet; Q80ZQ5; -.
DR PhosphoSitePlus; Q80ZQ5; -.
DR PaxDb; Q80ZQ5; -.
DR PRIDE; Q80ZQ5; -.
DR ProteomicsDB; 268908; -. [Q80ZQ5-1]
DR ProteomicsDB; 268909; -. [Q80ZQ5-2]
DR Antibodypedia; 26034; 124 antibodies from 22 providers.
DR DNASU; 231986; -.
DR Ensembl; ENSMUST00000074541; ENSMUSP00000074129; ENSMUSG00000063568. [Q80ZQ5-1]
DR GeneID; 231986; -.
DR KEGG; mmu:231986; -.
DR UCSC; uc009bza.2; mouse. [Q80ZQ5-1]
DR CTD; 221895; -.
DR MGI; MGI:2141450; Jazf1.
DR VEuPathDB; HostDB:ENSMUSG00000063568; -.
DR eggNOG; KOG4124; Eukaryota.
DR GeneTree; ENSGT00390000003635; -.
DR HOGENOM; CLU_077501_0_0_1; -.
DR InParanoid; Q80ZQ5; -.
DR OMA; EHIEDTH; -.
DR OrthoDB; 1617085at2759; -.
DR PhylomeDB; Q80ZQ5; -.
DR TreeFam; TF324161; -.
DR BioGRID-ORCS; 231986; 2 hits in 75 CRISPR screens.
DR ChiTaRS; Jazf1; mouse.
DR PRO; PR:Q80ZQ5; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q80ZQ5; protein.
DR Bgee; ENSMUSG00000063568; Expressed in animal zygote and 209 other tissues.
DR Genevisible; Q80ZQ5; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0001650; C:fibrillar center; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0017053; C:transcription repressor complex; ISO:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003714; F:transcription corepressor activity; ISO:MGI.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR InterPro; IPR030436; JAZF1.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23057:SF1; PTHR23057:SF1; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Lipid metabolism; Metal-binding; Nucleus;
KW Phosphoprotein; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..243
FT /note="Juxtaposed with another zinc finger protein 1"
FT /id="PRO_0000046986"
FT ZN_FING 12..37
FT /note="C2H2-type 1"
FT ZN_FING 173..198
FT /note="C2H2-type 2"
FT ZN_FING 208..230
FT /note="C2H2-type 3; degenerate"
FT REGION 39..79
FT /note="Required for interaction with NR2C2"
FT /evidence="ECO:0000250|UniProtKB:Q86VZ6"
FT REGION 89..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..147
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 109
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 113
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 64
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_007756"
FT CONFLICT 211
FT /note="R -> L (in Ref. 1; BAC34275)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 243 AA; 27098 MW; 878A6EE3D82C0348 CRC64;
MTGIAAASFF SNTCRFGGCG LHFPTLADLI EHIEDNHIDT DPRVLEKQEL QQPTYVALSY
INRFMTDAAR REQESLKKKI QPKLSLTLSS SVSRGNVSTP PRHSSGSLTP PVTPPITPSS
SFRSSTPTGS EYDEEEVDYE ESDSDESWTT ESAISSEAIL SSMCMNGGEE KPFACPVPGC
KKRYKNVNGI KYHAKNGHRT QIRVRKPFKC RCGKSYKTAQ GLRHHTINFH PPVSAEMIRK
MQQ
