ID   JAZF1_PONAB             Reviewed;         243 AA.
AC   Q5RDF5;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Juxtaposed with another zinc finger protein 1;
GN   Name=JAZF1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a transcriptional corepressor of orphan nuclear
CC       receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2
CC       through inhibition of NR2C2 activity. Also involved in transcriptional
CC       activation of NAMPT by promoting expression of PPARA and PPARD. Plays a
CC       role in lipid metabolism by suppressing lipogenesis, increasing
CC       lipolysis and decreasing lipid accumulation in adipose tissue. Plays a
CC       role in glucose homeostasis by improving glucose metabolism and insulin
CC       sensitivity. {ECO:0000250|UniProtKB:Q80ZQ5,
CC       ECO:0000250|UniProtKB:Q86VZ6}.
CC   -!- SUBUNIT: Interacts with NR2C2 (via ligand-binding region).
CC       {ECO:0000250|UniProtKB:Q86VZ6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q86VZ6}.
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DR   EMBL; CR857957; CAH90202.1; -; mRNA.
DR   RefSeq; NP_001125076.1; NM_001131604.1.
DR   AlphaFoldDB; Q5RDF5; -.
DR   STRING; 9601.ENSPPYP00000019829; -.
DR   Ensembl; ENSPPYT00000020612; ENSPPYP00000019829; ENSPPYG00000017691.
DR   GeneID; 100171957; -.
DR   KEGG; pon:100171957; -.
DR   CTD; 221895; -.
DR   eggNOG; KOG4124; Eukaryota.
DR   GeneTree; ENSGT00390000003635; -.
DR   InParanoid; Q5RDF5; -.
DR   OrthoDB; 1617085at2759; -.
DR   Proteomes; UP000001595; Chromosome 7.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0017053; C:transcription repressor complex; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   InterPro; IPR030436; JAZF1.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR23057:SF1; PTHR23057:SF1; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
PE   2: Evidence at transcript level;
KW   Lipid metabolism; Metal-binding; Nucleus; Phosphoprotein;
KW   Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..243
FT                   /note="Juxtaposed with another zinc finger protein 1"
FT                   /id="PRO_0000046987"
FT   ZN_FING         12..37
FT                   /note="C2H2-type 1"
FT   ZN_FING         173..198
FT                   /note="C2H2-type 2"
FT   ZN_FING         208..230
FT                   /note="C2H2-type 3; degenerate"
FT   REGION          39..79
FT                   /note="Required for interaction with NR2C2"
FT                   /evidence="ECO:0000250|UniProtKB:Q86VZ6"
FT   REGION          89..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..106
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        131..147
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         109
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q80ZQ5"
FT   MOD_RES         113
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86VZ6"
SQ   SEQUENCE   243 AA;  27079 MW;  878A6EE3D82C0588 CRC64;
     MTGIAAASFF SNTCRFGGCG LHFPTLADLI EHIEDNHIDT DPRVLEKQEL QQPTYVALSY
     INRFMTDAAR REQESLKKKI QPKLSLTLSS SVSRGNVSTP PRHSSGSLTP PVTPPITPSS
     SFRSSTPTGS EYDEEEVDYE ESDSDESWTT ESAISSEAIL SSMCMNGGEE KPFACPVPGC
     KKRYKNVNGI KYHAKNGHRT QIRVRKPFKC RCGKSYKTAQ GLRHHTINFH PPVSAEIIRK
     MQQ