JCAD_BOVIN
ID JCAD_BOVIN Reviewed; 1305 AA.
AC A2VE02;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Junctional cadherin 5-associated protein {ECO:0000305};
DE AltName: Full=Junctional protein associated with coronary artery disease homolog;
DE Short=JCAD;
GN Name=JCAD;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC {ECO:0000250|UniProtKB:Q5DTX6}. Note=Colocalizes with CDH5/VE-Cadherin
CC in endothelial cells but not in epithelial cells.
CC {ECO:0000250|UniProtKB:Q5DTX6}.
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DR EMBL; BC133502; AAI33503.1; -; mRNA.
DR RefSeq; NP_001075943.1; NM_001082474.1.
DR AlphaFoldDB; A2VE02; -.
DR STRING; 9913.ENSBTAP00000001595; -.
DR PaxDb; A2VE02; -.
DR PRIDE; A2VE02; -.
DR Ensembl; ENSBTAT00000001595; ENSBTAP00000001595; ENSBTAG00000001204.
DR Ensembl; ENSBTAT00000086679; ENSBTAP00000066527; ENSBTAG00000001204.
DR GeneID; 784675; -.
DR KEGG; bta:784675; -.
DR CTD; 57608; -.
DR VEuPathDB; HostDB:ENSBTAG00000001204; -.
DR VGNC; VGNC:56189; JCAD.
DR eggNOG; ENOG502QURJ; Eukaryota.
DR GeneTree; ENSGT00390000015348; -.
DR HOGENOM; CLU_005347_0_0_1; -.
DR InParanoid; A2VE02; -.
DR OMA; STFHTSE; -.
DR OrthoDB; 208373at2759; -.
DR Proteomes; UP000009136; Chromosome 13.
DR Bgee; ENSBTAG00000001204; Expressed in ampulla of uterine tube and 105 other tissues.
DR GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0032587; C:ruffle membrane; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:1903589; P:positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; IBA:GO_Central.
DR GO; GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:1900748; P:positive regulation of vascular endothelial growth factor signaling pathway; IEA:Ensembl.
DR InterPro; IPR028221; JCAD.
DR PANTHER; PTHR34757; PTHR34757; 1.
DR Pfam; PF15351; JCAD; 1.
PE 2: Evidence at transcript level;
KW Cell adhesion; Cell junction; Phosphoprotein; Reference proteome.
FT CHAIN 1..1305
FT /note="Junctional cadherin 5-associated protein"
FT /id="PRO_0000314184"
FT REGION 13..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 616..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 818..1005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1062..1166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1234..1305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..32
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..328
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..359
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..378
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..545
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 579..604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..703
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..760
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..843
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 865..893
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1278..1305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 841
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5DTX6"
FT MOD_RES 1004
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9P266"
FT MOD_RES 1010
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5DTX6"
FT MOD_RES 1152
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9P266"
FT MOD_RES 1239
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5DTX6"
SQ SEQUENCE 1305 AA; 140176 MW; F31D34AA5F4EBA1A CRC64;
MYSVEDLLIS HGYKLSRKLP APHEDDGERR QPARTTVPAG PGLLNGCDDG PAALPRGKAS
PGTGLLSDPE SRRLGPRGHG ERPSTAAAAR ISEAGFYHQP VLAWSSQPLT GRSHAYWRRR
EQEAREDPGG RGPVPSLPTH PREGPWEVGG RSEHVMKKAV WEDELGMAGP ARWQDVSVRS
WNQPPRLGRQ MSDGVGEKLF QDLYPFMLGE HGLTSQSKGK SQSLPRVLSP ESLSCMEVPI
PLSDGHLPGV PKVPLQPPNC ASNLESTRNP KKAGTSAPLP QPRFGRPLKP PSYGSQPHSK
AGAENGSYTD SRQLDPGAAH SARTNSARQD LYGPDPGLEP PVYVPPPSYK SPPQPAAHPC
PEEAVSRHEG RGRRVPQHPM ERPAAGGQPL SGSRGAGSEW GASPCSPVGV PPQPHHTTAY
DGSILIIPFD DPRIRHIKLP RPHGFWEDVK LDGAVPAPDP RSLQQEGAVW GPSGKERGPA
PADPSPSWLW GQPPRNGENG SSPDQRDPCI VTQRKQPDVS GSPQEYPESL VSSPSPQGES
SCEMQTQLRK FEAGLQPKRS SKKKTSETIF CLVSIPVKSE SQLPGTDTNN NDLKQSASLQ
EQSVLSLSST DLELQALTGS MATRTELPRP DPGGPGRGRQ ADDLRFPSPA KHRALAWPGP
WPGHHFRDQQ TQTSFAHEPQ SLQPLPGERP GGSPDPVLPP RCLDPAPFEV QMHMALASSD
PNQRPGAHSP KSQGSLSPSS NSAFSGSSWP RNQGPVPRAS LGQQGSDGPG RRASPVSRGE
VIKGETTGPC NSRQLFGQFL LKPVSRRPWD LISQLESFNK ELQEEEGSSG SSSDGSGSED
SDTELPWGSC ARPAPQLPGL LKDIVPEDPR TRPGRVKSKS ESWSEEGRPR SPRPWQAEGR
GSVWLSPPGS WIAEDGDREV EDRVAQLAVS PRPVKRAISS GLNDAKPEPP PDPAEQREPL
PSQELPGSRG AVELSAAGPP RAGGGEQGST RAPLSLAGKS RGLSAPDLRS VGLTLVQEHS
TSQLAGSPGD ANAIEIPPNE SLEARAARIL GIEVAVESLL PGAQRAGQRR HPEPDGSALR
PESPRQEAAA SLAQPNESTA PADAFYGRRK CGWTKSPLFV GERDSTRQVP RASEPADVDG
AVPTKAPETP PSPLESQPFL PKDVETKPPF RSTLFHFIER TPNLAFSEKK LRNTSRVIES
LQEKLVSPPR KADPDRLTRM KEVSSVSRMR LLTSRAADSA EEPKAERGPG AWLGGLVAPS
AGHKLSDPQG ALSLEADGHP AARRENGGRD FWCPDSYDPS RVERV
