JDP_DROME
ID JDP_DROME Reviewed; 195 AA.
AC Q9TVP3; Q8IMI1; Q9V3I7;
DT 01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=J domain-containing protein;
DE AltName: Full=dJDP;
GN Name=jdp; ORFNames=CG2239;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS A AND B), AND TISSUE
RP SPECIFICITY.
RX PubMed=10542335; DOI=10.1016/s0167-4781(99)00162-1;
RA Hahn Y., Lee J., Seong C., Yoon J., Chung J.H.;
RT "Structural analysis of phylogenetically conserved J domain protein gene.";
RL Biochim. Biophys. Acta 1447:325-333(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
RX PubMed=10760603; DOI=10.1016/s0167-4781(00)00047-6;
RA Lee J., Hahn Y., Yun J.H., Mita K., Chung J.H.;
RT "Characterization of JDP genes, an evolutionarily conserved J domain-only
RT protein family, from human and moths.";
RL Biochim. Biophys. Acta 1491:355-363(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C).
RC STRAIN=Berkeley; TISSUE=Head;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=B; Synonyms=JDPb;
CC IsoId=Q9TVP3-1; Sequence=Displayed;
CC Name=A; Synonyms=JDPa;
CC IsoId=Q9TVP3-2; Sequence=VSP_001297;
CC Name=C;
CC IsoId=Q9TVP3-3; Sequence=VSP_009459;
CC -!- TISSUE SPECIFICITY: Expressed in the head.
CC {ECO:0000269|PubMed:10542335}.
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DR EMBL; AF192462; AAF12790.1; -; mRNA.
DR EMBL; AF192463; AAF12791.1; -; mRNA.
DR EMBL; AF132905; AAD51421.1; -; Genomic_DNA.
DR EMBL; AF132902; AAD51421.1; JOINED; Genomic_DNA.
DR EMBL; AF132903; AAD51421.1; JOINED; Genomic_DNA.
DR EMBL; AF132904; AAD51421.1; JOINED; Genomic_DNA.
DR EMBL; AF132905; AAD48755.1; -; Genomic_DNA.
DR EMBL; AF132902; AAD48755.1; JOINED; Genomic_DNA.
DR EMBL; AF132903; AAD48755.1; JOINED; Genomic_DNA.
DR EMBL; AF132904; AAD48755.1; JOINED; Genomic_DNA.
DR EMBL; AE014297; AAF57063.1; -; Genomic_DNA.
DR EMBL; AE014297; AAN14240.1; -; Genomic_DNA.
DR EMBL; AE014297; AAN14241.1; -; Genomic_DNA.
DR EMBL; AY060331; AAL25370.1; -; mRNA.
DR EMBL; BT011341; AAR96133.1; -; mRNA.
DR RefSeq; NP_651807.1; NM_143550.3. [Q9TVP3-1]
DR RefSeq; NP_733380.1; NM_170501.2. [Q9TVP3-2]
DR RefSeq; NP_733381.1; NM_170502.2. [Q9TVP3-3]
DR AlphaFoldDB; Q9TVP3; -.
DR SMR; Q9TVP3; -.
DR BioGRID; 68483; 2.
DR IntAct; Q9TVP3; 4.
DR STRING; 7227.FBpp0085043; -.
DR PaxDb; Q9TVP3; -.
DR DNASU; 43630; -.
DR EnsemblMetazoa; FBtr0085681; FBpp0085043; FBgn0027654. [Q9TVP3-1]
DR EnsemblMetazoa; FBtr0085682; FBpp0085044; FBgn0027654. [Q9TVP3-2]
DR EnsemblMetazoa; FBtr0085683; FBpp0085045; FBgn0027654. [Q9TVP3-3]
DR GeneID; 43630; -.
DR KEGG; dme:Dmel_CG2239; -.
DR UCSC; CG2239-RA; d. melanogaster. [Q9TVP3-1]
DR CTD; 43630; -.
DR FlyBase; FBgn0027654; jdp.
DR VEuPathDB; VectorBase:FBgn0027654; -.
DR eggNOG; KOG0691; Eukaryota.
DR GeneTree; ENSGT00940000167977; -.
DR HOGENOM; CLU_118857_0_0_1; -.
DR InParanoid; Q9TVP3; -.
DR OMA; RSNYDKW; -.
DR PhylomeDB; Q9TVP3; -.
DR BioGRID-ORCS; 43630; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 43630; -.
DR PRO; PR:Q9TVP3; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0027654; Expressed in brain and 19 other tissues.
DR ExpressionAtlas; Q9TVP3; baseline and differential.
DR Genevisible; Q9TVP3; DM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; ISS:FlyBase.
DR GO; GO:0051087; F:chaperone binding; ISS:FlyBase.
DR GO; GO:0051082; F:unfolded protein binding; ISS:FlyBase.
DR GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; ISS:FlyBase.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; -; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR029827; JDP1-like.
DR PANTHER; PTHR44500; PTHR44500; 1.
DR Pfam; PF00226; DnaJ; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; SSF46565; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Chaperone; Reference proteome.
FT CHAIN 1..195
FT /note="J domain-containing protein"
FT /id="PRO_0000071070"
FT DOMAIN 17..82
FT /note="J"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT REGION 126..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 103..115
FT /note="Missing (in isoform A)"
FT /evidence="ECO:0000303|PubMed:10760603"
FT /id="VSP_001297"
FT VAR_SEQ 116..195
FT /note="SMHWVTPKTKDRMLPETGGAAAQGPGTGAGCSSGGLTAASPNPAHRRASEGG
FT AALYYGSRKGEWGGENTDVANKFRNYEI -> VCDMGQELSEYREVVAPSPSLCLPSHF
FT LTSARREPRSLKVVLVSRCTASTLGLVF (in isoform C)"
FT /evidence="ECO:0000303|Ref.6"
FT /id="VSP_009459"
SQ SEQUENCE 195 AA; 21651 MW; BCEFAC4DBB76E752 CRC64;
MSAVDAIINY KRSPNEDFYG LLHCDENSSP EQIQAEYKVL ALQYHPDKNS GDKEAEAKFQ
QLKEAKETLC DPEKRAIYDK WRNSGISMSY KQWLGMKEHV GQVRRYTIAE KVDKESMHWV
TPKTKDRMLP ETGGAAAQGP GTGAGCSSGG LTAASPNPAH RRASEGGAAL YYGSRKGEWG
GENTDVANKF RNYEI
